MetaCyc Pathway: ppGpp metabolism in Escherichia coli ECRC101

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Nucleoside-diphosphate kinase:
GDP + ATP→GTP + ADP (EC 2.7.4.6)
MCAODC_12235 (ndk)
MCAODC_27370 (adk)
GTP diphosphokinase:
GTP + ATP→pppGpp + AMP + H+ (EC 2.7.6.5)
MCAODC_06065 (spoT)
MCAODC_10775 (relA)
Guanosine-5'-triphosphate,3'-diphosphate diphosphatase:
pppGpp + H2O→ppGpp + H+ + phosphate (EC 3.6.1.40)
MCAODC_01360 (apaH)
MCAODC_05110 (gppA)
MCAODC_12325 (ppx)
Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase:
pppGpp + H2O→GTP + diphosphate (EC 3.1.7.2)
MCAODC_06065 (spoT)
Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase:
ppGpp + H2O→GDP + diphosphate (EC 3.1.7.2)
MCAODC_06065 (spoT)
GTP diphosphokinase:
GDP + ATP→ppGpp + AMP + H+ (EC 2.7.6.5)
MCAODC_06065 (spoT)
MCAODC_10775 (relA)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information