MetaCyc Pathway: superpathway of hexuronide and hexuronate degradation in Escherichia coli ECRC101

Add experiment(s):


Beta-glucuronidase:
a β-D-glucuronide + H2O→D-glucopyranuronate + an alcohol (EC 3.2.1.31)
MCAODC_17795 (uidA)
MCAODC_17800 (lacZ)
Glucuronate isomerase:
aldehydo-D-galacturonate→D-tagaturonate (EC 5.3.1.12)
MCAODC_09035 (uxaC)
Tagaturonate reductase (in reverse):
D-tagaturonate + NADH + H+→D-altronate + NAD+ (EC 1.1.1.58)
MCAODC_16795 (uxaB)
D-glucopyranuronate→aldehydo-D-glucuronate (spontaneous)
No genes
Altronate dehydratase:
D-altronate→2-dehydro-3-deoxy-D-gluconate + H2O (EC 4.2.1.7)
MCAODC_09040 (uxaA)
Glucuronate isomerase:
aldehydo-D-glucuronate→D-fructuronate (EC 5.3.1.12)
MCAODC_09035 (uxaC)
Fructuronate reductase (in reverse):
D-fructuronate + NADH + H+→D-mannonate + NAD+ (EC 1.1.1.57)
MCAODC_02075 (uxuB)
MCAODC_14465 (yeiQ)
MCAODC_16925 (ydfI)
Mannonate dehydratase:
D-mannonate→2-dehydro-3-deoxy-D-gluconate + H2O (EC 4.2.1.8)
MCAODC_02080 (uxuA)
2-dehydro-3-deoxy-D-gluconate + ATP→2-dehydro-3-deoxy-D-gluconate 6-phosphate + ADP + H+ (EC 2.7.1.178; 2.7.1.45)
MCAODC_06720 (kdgK)
2-dehydro-3-deoxy-phosphogluconate aldolase:
2-dehydro-3-deoxy-D-gluconate 6-phosphate→D-glyceraldehyde 3-phosphate + pyruvate (EC 4.1.2.14; 4.1.2.55)
MCAODC_19060 (kdgA)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information