MetaCyc Pathway: pyrimidine deoxyribonucleotides de novo biosynthesis I in Escherichia coli ECRC101

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Nucleoside-triphosphatase:
CTP + H2O→CDP + H+ + phosphate (EC 3.6.1.15; 3.6.1.5)
OKFHMN_19240 (rdgB)
Ribonucleoside-diphosphate reductase (in reverse):
UDP + a reduced thioredoxin→dUDP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
OKFHMN_20825 (nrdF)
OKFHMN_20830 (nrdE)
OKFHMN_20835
OKFHMN_20840 (nrdI)
OKFHMN_23105 (nrdB)
OKFHMN_23115 (nrdA)
Ribonucleoside-diphosphate reductase (in reverse):
CDP + a reduced thioredoxin→dCDP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
OKFHMN_20825 (nrdF)
OKFHMN_20830 (nrdE)
OKFHMN_20835
OKFHMN_20840 (nrdI)
OKFHMN_23105 (nrdB)
OKFHMN_23115 (nrdA)
Nucleoside-diphosphate kinase:
dUDP + ATP→dUTP + ADP (EC 2.7.4.6)
OKFHMN_21705 (ndk)
Nucleoside-diphosphate kinase:
dCDP + ATP→dCTP + ADP (EC 2.7.4.6)
OKFHMN_08145 (adk)
OKFHMN_21705 (ndk)
dUTP diphosphatase:
dUTP + H2O→dUMP + diphosphate + H+ (EC 3.6.1.23; 3.6.1.9)
OKFHMN_15610 (dut)
OKFHMN_23005 (nudI)
Thymidylate synthase:
dUMP + a 5,10-methylenetetrahydrofolate→dTMP + a 7,8-dihydrofolate (EC 2.1.1.45)
OKFHMN_20015 (thyA)
T(2)-induced deoxynucleotide kinase:
dTMP + ATP→dTDP + ADP (EC 2.7.4.12; 2.7.4.13; 2.7.4.9)
OKFHMN_03550 (tmk)
Nucleoside-diphosphate kinase:
dTDP + ATP→dTTP + ADP (EC 2.7.4.6)
OKFHMN_08145 (adk)
OKFHMN_21705 (ndk)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information