MetaCyc Pathway: superpathway of L-phenylalanine biosynthesis in Escherichia coli ECRC101

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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
OKFHMN_06740 (aroG)
OKFHMN_21215 (aroF)
OKFHMN_27135 (aroH)
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
OKFHMN_17115 (aroB)
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
OKFHMN_20275 (eno)
OKFHMN_27195 (aroD)
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
OKFHMN_17565 (aroE)
OKFHMN_27200 (ydiB)
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
OKFHMN_08600 (aroL)
OKFHMN_17110 (aroK)
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
OKFHMN_05485 (aroA)
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
OKFHMN_22615 (aroC)
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
OKFHMN_21220 (tyrA)
OKFHMN_21225 (pheA)
Prephenate dehydratase:
prephenate + H+→3-phenyl-2-oxopropanoate + CO2 + H2O (EC 4.2.1.51)
OKFHMN_21225 (pheA)
Aspartate transaminase (in reverse):
3-phenyl-2-oxopropanoate + L-glutamate→L-phenylalanine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
OKFHMN_01580 (ydcR)
OKFHMN_05385 (aspC)
OKFHMN_11450 (yjiR)
OKFHMN_12920 (tyrB)
OKFHMN_14645 (ilvE)
OKFHMN_20855 (aRO8)
OKFHMN_24510 (hisC)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information