MetaCyc Pathway: superpathway of hexitol degradation (bacteria) in Escherichia coli ECRC100

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Mannitol-1-phosphate 5-dehydrogenase:
D-mannitol 1-phosphate + NAD+→β-D-fructofuranose 6-phosphate + NADH + H+ (EC 1.1.1.17)
OKFHMN_15810 (mtlD)
Sorbitol-6-phosphate 2-dehydrogenase:
D-sorbitol 6-phosphate + NAD+→keto-D-fructose 6-phosphate + NADH + H+ (EC 1.1.1.140)
OKFHMN_13200 (fabG)
OKFHMN_20670 (srlD)
galactitol[out] + an [HPr protein]-Nπ-phospho-L-histidine[in]→galactitol 1-phosphate[in] + an [HPr]-L-histidine[in] (EC 2.7.1.200)
OKFHMN_24125 (gatA)
OKFHMN_24130 (gatB)
OKFHMN_24135 (gatB)
Galactitol-1-phosphate 5-dehydrogenase:
galactitol 1-phosphate + NAD+→keto-D-tagatose 6-phosphate + NADH + H+ (EC 1.1.1.251)
OKFHMN_24140 (gatD)
6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
OKFHMN_13830 (pfkA)
OKFHMN_27035 (pfkB)
Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
OKFHMN_12730 (fba)
OKFHMN_16490 (fba)
OKFHMN_19395 (fbaA)
OKFHMN_24105 (fbaB)
Fructose-bisphosphatase:
β-D-fructofuranose 1,6-bisphosphate + H2O→β-D-fructofuranose 6-phosphate + phosphate (EC 3.1.3.11)
OKFHMN_06680 (ybhA)
OKFHMN_08625 (phoA)
OKFHMN_11945 (fbp)
OKFHMN_13780 (glpX)
OKFHMN_19345 (glpX)
keto-D-tagatose 6-phosphate→D-tagatofuranose 6-phosphate (spontaneous)
No genes
Tagatose-6-phosphate kinase:
D-tagatofuranose 6-phosphate + ATP→D-tagatofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.144)
OKFHMN_13830 (pfkA)
OKFHMN_18335 (kbaZ)
OKFHMN_23440 (fruB)
OKFHMN_24120 (gatZ)
OKFHMN_27035 (pfkB)
Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
OKFHMN_13810 (tpiA)
Tagatose-bisphosphate aldolase:
D-tagatofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.40)
OKFHMN_12730 (fba)
OKFHMN_16490 (fba)
OKFHMN_18300 (kbaY)
OKFHMN_18335 (kbaZ)
OKFHMN_24115 (gatY)
OKFHMN_24120 (gatZ)
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
OKFHMN_01695 (gap)
OKFHMN_26730 (gapA)
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
OKFHMN_19390 (pgk)
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
OKFHMN_06735 (gpmA)
OKFHMN_11155
OKFHMN_15735 (gpmM)
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.11)
OKFHMN_06735 (gpmA)
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
OKFHMN_20275 (eno)
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
OKFHMN_26320 (pyk)
OKFHMN_27290 (pykF)
Pyruvate, water dikinase:
pyruvate + ATP + H2O→phosphoenolpyruvate + AMP + 2 H+ + phosphate (EC 2.7.9.2)
OKFHMN_27145 (ppsA)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information