MetaCyc Pathway: superpathway of L-aspartate and L-asparagine biosynthesis in Escherichia coli ECRC101

Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)

OKFHMN_01580 (ydcR)

OKFHMN_05385 (aspC)

OKFHMN_11450 (yjiR)

OKFHMN_20855 (aRO8)

Aspartate ammonia-lyase (in reverse):
fumarate + ammonium→L-aspartate (EC 4.3.1.1)

OKFHMN_12430 (aspA)

Aspartate--ammonia ligase:
L-aspartate + ammonium + ATP→L-asparagine + AMP + diphosphate + H⁺ (EC 6.3.1.1)

OKFHMN_07180 (asnB)

OKFHMN_14770 (asnA)

Asparaginase:
L-asparagine + H₂O→L-aspartate + ammonium (EC 3.5.1.1; 3.5.1.38; 3.5.5.4)

OKFHMN_19220 (ansB)

OKFHMN_26805 (ansA)

Links:

Pathway details at MetaCyc
Fitness data for 9 genes
Select organism:
All MetaCyc pathways for Escherichia coli ECRC101

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information