MetaCyc Pathway: superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation in Escherichia coli ECRC101

Add experiment(s):


Arginine decarboxylase:
L-arginine + H+→agmatine + CO2 (EC 4.1.1.19)
OKFHMN_12550 (adiA)
OKFHMN_19305 (speA)
Agmatinase:
agmatine + H2O→putrescine + urea (EC 3.5.3.11)
OKFHMN_19315 (speB)
Putrescine aminotransferase:
putrescine + 2-oxoglutarate→4-aminobutanal + L-glutamate (EC 2.6.1.82)
OKFHMN_18625 (ygjG)
Glutamate--putrescine ligase:
putrescine + ATP + L-glutamate→γ-glutamyl-L-putrescine + ADP + H+ + phosphate (EC 6.3.1.11)
OKFHMN_02445 (puuA)
Aminobutyraldehyde dehydrogenase:
4-aminobutanal + NAD+ + H2O→4-aminobutanoate + NADH + 2 H+ (EC 1.2.1.19)
OKFHMN_01555 (patD)
OKFHMN_02430 (puuC)
γ-glutamyl-L-putrescine + dioxygen + H2O→4-(γ-L-glutamylamino)butanal + ammonium + hydrogen peroxide (EC 1.4.3.M3)
OKFHMN_02425 (puuB)
4-(γ-L-glutamylamino)butanal + NAD(P)+ + H2O→4-(γ-L-glutamylamino)butanoate + NAD(P)H + 2 H+ (EC 1.2.1.99)
OKFHMN_02430 (puuC)
Gamma-glutamyl-gamma-aminobutyrate hydrolase:
4-(γ-L-glutamylamino)butanoate + H2O→4-aminobutanoate + L-glutamate (EC 3.5.1.94)
OKFHMN_02440 (puuD)
4-aminobutyrate transaminase:
4-aminobutanoate + 2-oxoglutarate→succinate semialdehyde + L-glutamate (EC 2.6.1.19)
OKFHMN_02420 (puuE)
OKFHMN_20910 (gabT)
Succinate-semialdehyde dehydrogenase:
succinate semialdehyde + NAD+ + H2O→succinate + NADH + 2 H+ (EC 1.2.1.24)
OKFHMN_01110 (sad)
OKFHMN_02430 (puuC)
succinate semialdehyde + NADP+ + H2O→succinate + NADPH + 2 H+ (EC 1.2.1.79)
OKFHMN_20915 (gabD)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information