MetaCyc Pathway: TCA cycle I (prokaryotic) in Escherichia coli ECOR38

Add experiment(s):


2-oxoglutarate + coenzyme A + NAD+→succinyl-CoA + CO2 + NADH (EC 1.2.1.105)
HEPCGN_08470 (lpdA)
Succinate--CoA ligase (ADP-forming) (in reverse):
succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
HEPCGN_01315 (sucC)
HEPCGN_01320 (sucD)
Succinate dehydrogenase (ubiquinone):
succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol (EC 1.3.5.1)
No genes
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
HEPCGN_01375 (ttdA)
HEPCGN_05680 (fumD)
HEPCGN_06020 (fumB)
HEPCGN_06025 (fumC)
HEPCGN_11160 (fumB)
HEPCGN_18660 (fumE)
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38)
HEPCGN_01775 (hcxB)
HEPCGN_16660 (mdh)
HEPCGN_26435 (maeA)
(S)-malate[in] + an electron-transfer quinone→oxaloacetate[in] + an electron-transfer quinol (EC 1.1.5.4)
HEPCGN_22490 (mqo)
Citrate (Si)-synthase:
oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
HEPCGN_01275 (gltA)
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
HEPCGN_01620 (acnA)
HEPCGN_08460 (acnB)
HEPCGN_25625 (acnA)
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
HEPCGN_01620 (acnA)
HEPCGN_08460 (acnB)
HEPCGN_25625 (acnA)
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
HEPCGN_24245 (icd)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information