MetaCyc Pathway: gluconeogenesis III in Escherichia coli ECOR38

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Pyruvate carboxylase:
pyruvate + ATP + hydrogen carbonate→oxaloacetate + ADP + H+ + phosphate (EC 6.4.1.1)
No genes
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38)
HEPCGN_01775 (hcxB)
HEPCGN_16660 (mdh)
HEPCGN_26435 (maeA)
Phosphoenolpyruvate carboxykinase (GTP):
oxaloacetate + GTP→phosphoenolpyruvate + CO2 + GDP (EC 4.1.1.32)
No genes
Phosphopyruvate hydratase (in reverse):
phosphoenolpyruvate + H2O→2-phospho-D-glycerate (EC 4.2.1.11)
HEPCGN_19525 (eno)
2-phospho-D-glycerate→3-phospho-D-glycerate (EC 5.4.2.11)
HEPCGN_01540 (gpmA)
Phosphoglycerate kinase:
3-phospho-D-glycerate + ATP→3-phospho-D-glyceroyl phosphate + ADP (EC 2.7.2.3)
HEPCGN_18700 (pgk)
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (in reverse):
3-phospho-D-glyceroyl phosphate + NADH + H+→D-glyceraldehyde 3-phosphate + NAD+ + phosphate (EC 1.2.1.12)
HEPCGN_05120 (gapA)
HEPCGN_26125 (gap)
Triose-phosphate isomerase:
D-glyceraldehyde 3-phosphate→glycerone phosphate (EC 5.3.1.1)
HEPCGN_12455 (tpiA)
Fructose-bisphosphate aldolase (in reverse):
glycerone phosphate + D-glyceraldehyde 3-phosphate→β-D-fructofuranose 1,6-bisphosphate (EC 4.1.2.13)
HEPCGN_02790 (fbaB)
HEPCGN_14330
HEPCGN_14335 (fba)
HEPCGN_15410 (fba)
HEPCGN_18705 (fbaA)
Fructose-bisphosphatase:
β-D-fructofuranose 1,6-bisphosphate + H2O→β-D-fructofuranose 6-phosphate + phosphate (EC 3.1.3.11)
HEPCGN_01595 (ybhA)
HEPCGN_07265 (phoA)
HEPCGN_10145 (fbp)
HEPCGN_12425 (glpX)
HEPCGN_18655 (glpX)
Glucose-6-phosphate isomerase (in reverse):
β-D-fructofuranose 6-phosphate→α-D-glucose 6-phosphate (EC 5.3.1.9)
HEPCGN_11685 (pgi)
HEPCGN_19590 (kduI)
Sugar-terminal-phosphatase:
D-glucopyranose 6-phosphate + H2O→D-glucopyranose + phosphate (EC 3.1.3.58; 3.1.3.9)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information