MetaCyc Pathway: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage in Escherichia coli ECOR38

Add experiment(s):


1-deoxy-D-xylulose-5-phosphate synthase:
D-glyceraldehyde 3-phosphate + pyruvate + H+→1-deoxy-D-xylulose 5-phosphate + CO2 (EC 2.2.1.7)
HEPCGN_07050 (dxs)
Erythrose-4-phosphate dehydrogenase:
D-erythrose 4-phosphate + NAD+ + H2O→4-phospho-D-erythronate + NADH + 2 H+ (EC 1.2.1.72)
HEPCGN_05120 (gapA)
HEPCGN_18695 (epd)
HEPCGN_26125 (gap)
Pyridoxal kinase:
pyridoxamine + ATP→pyridoxamine 5'-phosphate + ADP + H+ (EC 2.7.1.35)
HEPCGN_05890 (pdxY)
HEPCGN_21355 (pdxK)
Pyridoxine 4-dehydrogenase (in reverse):
pyridoxal + NADPH + H+→pyridoxine + NADP+ (EC 1.1.1.65)
HEPCGN_26075 (pdxI)
Pyridoxal kinase:
pyridoxal + ATP→pyridoxal 5'-phosphate + ADP + H+ (EC 2.7.1.35)
HEPCGN_05890 (pdxY)
HEPCGN_21355 (pdxK)
4-phosphoerythronate dehydrogenase:
4-phospho-D-erythronate + NAD+→(3R)-3-hydroxy-2-oxo-4 phosphooxybutanoate + NADH + H+ (EC 1.1.1.290)
HEPCGN_21865 (pdxB)
Pyridoxal 5'-phosphate synthase:
pyridoxamine 5'-phosphate + dioxygen + H2O→pyridoxal 5'-phosphate + ammonium + hydrogen peroxide (EC 1.4.3.5)
HEPCGN_05880 (pdxH)
Pyridoxal kinase:
pyridoxine + ATP→pyridoxine 5'-phosphate + ADP + H+ (EC 2.7.1.35)
HEPCGN_05890 (pdxY)
HEPCGN_21355 (pdxK)
Phosphoserine transaminase (in reverse):
(3R)-3-hydroxy-2-oxo-4 phosphooxybutanoate + L-glutamate→4-phosphooxy-L-threonine + 2-oxoglutarate (EC 2.6.1.52)
HEPCGN_23030 (serC)
4-hydroxythreonine-4-phosphate dehydrogenase:
4-phosphooxy-L-threonine + NAD+→3-amino-1-hydroxyacetone 1-phosphate + CO2 + NADH (EC 1.1.1.262)
HEPCGN_08820 (pdxA)
Pyridoxine 5'-phosphate synthase:
3-amino-1-hydroxyacetone 1-phosphate + 1-deoxy-D-xylulose 5-phosphate→pyridoxine 5'-phosphate + H+ + phosphate + 2 H2O (EC 2.6.99.2)
HEPCGN_20570 (pdxJ)
Pyridoxal 5'-phosphate synthase:
pyridoxine 5'-phosphate + dioxygen→pyridoxal 5'-phosphate + hydrogen peroxide (EC 1.4.3.5)
HEPCGN_05880 (pdxH)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information