MetaCyc Pathway: L-lysine degradation I in Escherichia coli ECOR38

Add experiment(s):


Lysine decarboxylase:
L-lysine + H+→cadaverine + CO2 (EC 4.1.1.18)
HEPCGN_08080 (ldcC)
HEPCGN_11110 (cadA)
Putrescine aminotransferase:
cadaverine + 2-oxoglutarate→5-aminopentanal + L-glutamate (EC 2.6.1.82)
HEPCGN_17475 (ygjG)
Aminobutyraldehyde dehydrogenase:
5-aminopentanal + NAD+ + H2O→5-aminopentanoate + NADH + 2 H+ (EC 1.2.1.19)
HEPCGN_26255 (patD)
5-aminovalerate transaminase:
2-oxoglutarate + 5-aminopentanoate→glutarate semialdehyde + L-glutamate (EC 2.6.1.48)
HEPCGN_20155 (gabT)
HEPCGN_25780 (puuE)
Glutarate-semialdehyde dehydrogenase:
glutarate semialdehyde + NADP+ + H2O→glutarate + NADPH + 2 H+ (EC 1.2.1.20)
HEPCGN_20150 (gabD)
HEPCGN_26650 (sad)
2-oxoglutarate + glutarate + dioxygen→(S)-2-hydroxyglutarate + CO2 + succinate (EC 1.14.11.64)
HEPCGN_20140 (csiD)
(S)-2-hydroxyglutarate + an electron-transfer quinone→2-oxoglutarate + an electron-transfer quinol (EC 1.1.5.13)
HEPCGN_20145 (lhgO)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information