MetaCyc Pathway: ADP-L-glycero-β-D-manno-heptose biosynthesis in Escherichia coli ECOR38

Add experiment(s):


D-sedoheptulose 7-phosphate→D-glycero-D-manno-heptose 7-phosphate (EC 5.3.1.28)
HEPCGN_07880 (lpcA)
HEPCGN_17095 (diaA)
D-glycero-D-manno-heptose 7-phosphate + ATP→D-glycero-β-D-manno-heptose 1,7-bisphosphate + ADP + H+ (EC 2.7.1.167)
HEPCGN_17590 (hldE)
D-glycero-β-D-manno-heptose 1,7-bisphosphate + H2O→D-glycero-β-D-manno-heptose 1-phosphate + phosphate (EC 3.1.3.82)
HEPCGN_07985 (gmhB)
D-glycero-β-D-manno-heptose 1-phosphate + ATP + H+→ADP-D-glycero-β-D-manno-heptose + diphosphate (EC 2.7.7.70)
HEPCGN_17590 (hldE)
ADP-glyceromanno-heptose 6-epimerase:
ADP-D-glycero-β-D-manno-heptose→ADP-L-glycero-β-D-manno-heptose (EC 5.1.3.20)
HEPCGN_14545 (rfaD)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information