MetaCyc Pathway: 8-amino-7-oxononanoate biosynthesis IV in Escherichia coli ECOR38

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glutaryl-CoA + a malonyl-[acp] + H+→a 3-oxopimeloyl-[acp] + CO2 + coenzyme A
No genes
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxopimeloyl-[acp] + NADPH + H+→a (3R)-3-hydroxypimeloyl-[acp] + NADP+ (EC 1.1.1.100)
HEPCGN_01245
HEPCGN_02205 (yohF)
HEPCGN_10295 (fabG)
HEPCGN_21320 (ucpA)
HEPCGN_23905 (fabG)
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxypimeloyl-[acp]→a 2-enoyl-pimeloyl-[acp] + H2O (EC 4.2.1.59)
HEPCGN_08110 (fabZ)
HEPCGN_23270 (fabA)
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a 2-enoyl-pimeloyl-[acp] + NADH + H+→a pimeloyl-[acp] + NAD+ (EC 1.3.1.9)
HEPCGN_25690 (fabI_F203V)
8-amino-7-oxononanoate synthase:
a pimeloyl-[acp] + L-alanine + H+→(8S)-8-amino-7-oxononanoate + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.47)
HEPCGN_01645 (bioF)
HEPCGN_17965

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information