MetaCyc Pathway: 1,3-propanediol biosynthesis (engineered) in Escherichia coli ECOR38

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D-glucose[out] + H+[out]→D-glucose[in] + H+[in]
HEPCGN_18600 (galP)
Hexokinase:
D-glucopyranose + ATP→D-glucopyranose 6-phosphate + ADP + H+ (EC 2.7.1.1; 2.7.1.2)
HEPCGN_07205 (mak)
HEPCGN_21530 (glk)
Glucose-6-phosphate isomerase:
α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate (EC 5.3.1.9)
HEPCGN_11685 (pgi)
HEPCGN_19590 (kduI)
6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
HEPCGN_05400 (pfkB)
HEPCGN_12475 (pfkA)
Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
HEPCGN_02790 (fbaB)
HEPCGN_14330
HEPCGN_14335 (fba)
HEPCGN_15410 (fba)
HEPCGN_18705 (fbaA)
Glycerol-3-phosphate dehydrogenase (NAD(+)) (in reverse):
glycerone phosphate + NADH + H+→sn-glycerol 3-phosphate + NAD+ (EC 1.1.1.8)
HEPCGN_14595 (gpsA)
Glycerol-1-phosphatase:
sn-glycerol 3-phosphate + H2O→glycerol + phosphate (EC 3.1.3.21)
No genes
Glycerol dehydratase:
glycerol→3-hydroxypropanal + H2O (EC 4.2.1.30)
No genes
3-hydroxypropanal + NADPH + H+→1,3-propanediol + NADP+
HEPCGN_17810 (yqhD)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information