Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4) |
| HEPCGN_09115 (thrA) |
| HEPCGN_11690 (lysC) |
| HEPCGN_12340 (metL) |
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11) |
| HEPCGN_15690 (asd) |
| HEPCGN_21870 (usg) |
| L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7) |
| HEPCGN_21085 (dapA) |
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3) |
| HEPCGN_09115 (thrA) |
| HEPCGN_12340 (metL) |
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39) |
| HEPCGN_09110 (thrB) |
| (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8) |
| HEPCGN_08940 (dapB) |
Cystathionine gamma-synthase:
O-phospho-L-homoserine + L-cysteine→L-cystathionine + phosphate (EC 2.5.1.48) |
| HEPCGN_12345 (metB) |
LL-diaminopimelate aminotransferase (in reverse):
(S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H+ + H2O→L,L-diaminopimelate + 2-oxoglutarate (EC 2.6.1.83) |
| No genes |
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1) |
| HEPCGN_09105 (thrC) |
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate (EC 5.1.1.7) |
| HEPCGN_04740 (zwf) |
| HEPCGN_13135 (dapF) |
Cysteine-S-conjugate beta-lyase:
L-cystathionine→2-aminoprop-2-enoate + L-homocysteine (EC 4.4.1.13) |
| No genes |
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2 (EC 4.1.1.20) |
| HEPCGN_19565 (lysA) |
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate (EC 2.1.1.14) |
| HEPCGN_13025 (metE) |
Tryptophanase:
2-aminoprop-2-enoate→2-iminopropanoate (spontaneous) (EC 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2) |
| HEPCGN_04150 (dcyD) |
| HEPCGN_04940 (sdaA) |
| HEPCGN_13670 (tnaA) |
| HEPCGN_14135 |
| HEPCGN_17260 (tdcG) |
| HEPCGN_19430 (sdaB) |
| HEPCGN_21655 (dsdA) |
| 2-iminopropanoate + H2O→pyruvate + ammonium (spontaneous) (EC 3.5.99.10; 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2) |
| HEPCGN_04150 (dcyD) |
| HEPCGN_04940 (sdaA) |
| HEPCGN_10070 (ridA) |
| HEPCGN_13670 (tnaA) |
| HEPCGN_14135 |
| HEPCGN_17255 (tdcF) |
| HEPCGN_17260 (tdcG) |
| HEPCGN_19430 (sdaB) |
| HEPCGN_21655 (dsdA) |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information