MetaCyc Pathway: superpathway of adenosine nucleotides de novo biosynthesis I in Escherichia coli ECOR38

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Adenylosuccinate synthase:
IMP + L-aspartate + GTP→adenylosuccinate + GDP + 2 H+ + phosphate (EC 6.3.4.4)
HEPCGN_10460 (purA)
Adenylosuccinate lyase:
adenylosuccinate→AMP + fumarate (EC 4.3.2.2)
HEPCGN_24210 (purB)
Adenylate kinase:
AMP + ATP→2 ADP (EC 2.7.4.3)
HEPCGN_06760 (adk)
Ribonucleoside-diphosphate reductase (in reverse):
ADP + a reduced thioredoxin→dADP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
HEPCGN_20025 (nrdF)
HEPCGN_20030 (nrdE)
HEPCGN_20035 (nrdI)
HEPCGN_22340 (nrdB)
HEPCGN_22345 (nrdA)
Nucleoside-diphosphate kinase:
dADP + ATP→ADP + dATP (EC 2.7.4.6)
HEPCGN_20825 (ndk)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information