MetaCyc Pathway: superpathway of L-tyrosine biosynthesis in Escherichia coli ECOR38

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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
HEPCGN_01535 (aroG)
HEPCGN_05500 (aroH)
HEPCGN_20335 (aroF)
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
HEPCGN_15935 (aroB)
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
HEPCGN_05580 (aroD)
HEPCGN_19525 (eno)
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
HEPCGN_05585 (ydiB)
HEPCGN_11860
HEPCGN_16385 (aroE)
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
HEPCGN_07240 (aroL)
HEPCGN_15930 (aroK)
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
HEPCGN_23035 (aroA)
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
HEPCGN_21820 (aroC)
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
HEPCGN_20340 (tyrA)
HEPCGN_20345 (pheA)
Prephenate dehydrogenase:
prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)
HEPCGN_20340 (tyrA)
Aspartate transaminase (in reverse):
3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
HEPCGN_03215 (hisC)
HEPCGN_11535 (tyrB)
HEPCGN_14250
HEPCGN_20050 (aRO8)
HEPCGN_23140 (aspC)
HEPCGN_26230 (ydcR)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information