MetaCyc Pathway: cis-vaccenate biosynthesis in Escherichia coli ECOR38

Add experiment(s):


Beta-ketoacyl-acyl-carrier-protein synthase II:
a palmitoleoyl-[acp] + a malonyl-[acp] + H+→an (11Z)-3-oxooctadec-11-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179)
HEPCGN_23915 (fabF)
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
an (11Z)-3-oxooctadec-11-enoyl-[acp] + NADPH + H+→a (3R,11Z)-3-hydroxyoctadec-11-enoyl-[acp] + NADP+ (EC 1.1.1.100)
HEPCGN_01245
HEPCGN_02205 (yohF)
HEPCGN_10295 (fabG)
HEPCGN_21320 (ucpA)
HEPCGN_23905 (fabG)
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R,11Z)-3-hydroxyoctadec-11-enoyl-[acp]→a (2E,11Z)-octadeca-2,11-dienoyl-[acp] + H2O (EC 4.2.1.59)
HEPCGN_08110 (fabZ)
HEPCGN_23270 (fabA)
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E,11Z)-octadeca-2,11-dienoyl-[acp] + NADH + H+→a cis-vaccenoyl-[acp] + NAD+ (EC 1.3.1.9)
HEPCGN_25690 (fabI_F203V)
Oleoyl-[acyl-carrier-protein] hydrolase:
a cis-vaccenoyl-[acp] + H2O→cis-vaccenate + a soluble [acyl-carrier protein] + H+ (EC 3.1.2.14)
HEPCGN_06605 (tesA)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information