MetaCyc Pathway: L-glutamate and L-glutamine biosynthesis in Escherichia coli ECOR38

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Glutamate dehydrogenase (NAD(P)(+)) (in reverse):
2-oxoglutarate + ammonium + NAD(P)H + H+→L-glutamate + NAD(P)+ + H2O (EC 1.4.1.3)
No genes
Glutamate synthase (ferredoxin) (in reverse):
2-oxoglutarate + L-glutamine + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→2 L-glutamate + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.4.7.1)
No genes
Glutamate synthase (NADH) (in reverse):
2-oxoglutarate + L-glutamine + NADH + H+→2 L-glutamate + NAD+ (EC 1.4.1.14)
HEPCGN_16755 (gltD)
Glutamate synthase (NADPH):
L-glutamine + H2O→L-glutamate + ammonia + H+ (EC 1.4.1.13; 1.4.1.14; 1.4.7.1; 2.6.1.85; 3.5.1.2; 3.5.1.38; 4.1.3.27; 4.3.2.10; 4.3.3.6; 6.3.4.2; 6.3.5.13; 6.3.5.2; 6.3.5.4; 6.3.5.5; 6.3.5.6; 6.3.5.7)
HEPCGN_01050 (asnB)
HEPCGN_03595 (ybtS)
HEPCGN_04950 (pabB)
HEPCGN_06705 (glsA)
HEPCGN_08925 (carB)
HEPCGN_08930 (carA)
HEPCGN_16050 (pabA)
HEPCGN_16755 (gltD)
HEPCGN_16760 (gltB3)
HEPCGN_18900 (ygfT)
HEPCGN_19520 (pyrG)
HEPCGN_20285 (ypjD)
HEPCGN_20905 (guaA)
HEPCGN_21150 (aegA)
HEPCGN_25530 (trpD)
HEPCGN_25535 (trpE)
HEPCGN_26645 (glsB)
Glutamate--ammonia ligase:
L-glutamate + ammonium + ATP→L-glutamine + ADP + H+ + phosphate (EC 6.3.1.2)
HEPCGN_12730 (glnA)
Glutamate dehydrogenase (NADP(+)) (in reverse):
2-oxoglutarate + ammonium + NADPH + H+→L-glutamate + NADP+ + H2O (EC 1.4.1.4)
HEPCGN_05205 (gdhA)
HEPCGN_16755 (gltD)
Glutamate synthase (NADPH) (in reverse):
2-oxoglutarate + ammonia + NADPH + 2 H+→L-glutamate + NADP+ + H2O (EC 1.4.1.13; 1.4.1.14)
HEPCGN_16755 (gltD)
HEPCGN_16760 (gltB3)
HEPCGN_18900 (ygfT)
HEPCGN_20285 (ypjD)
HEPCGN_21150 (aegA)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information