Guanine deaminase:
guanine + H+ + H2O→xanthine + ammonium (EC 3.5.4.3) |
| HEPCGN_18915 (guaD) |
Xanthine dehydrogenase:
hypoxanthine + NAD+ + H2O→6,8-dihydroxypurine + NADH + H+ (EC 1.17.1.4) |
| HEPCGN_18990 (xdhC) |
| HEPCGN_18995 (xdhB) |
| HEPCGN_19000 (xdhA) |
Xanthine dehydrogenase:
purine + NAD+ + H2O→8-hydroxypurine + NADH + H+ (EC 1.17.1.4) |
| HEPCGN_18990 (xdhC) |
| HEPCGN_18995 (xdhB) |
| HEPCGN_19000 (xdhA) |
| 8-hydroxypurine + NAD+ + H2O→6,8-dihydroxypurine + NADH + H+ |
| No genes |
Xanthine dehydrogenase:
6,8-dihydroxypurine + NAD+ + H2O→urate + NADH + H+ (EC 1.17.1.4) |
| HEPCGN_18990 (xdhC) |
| HEPCGN_18995 (xdhB) |
| HEPCGN_19000 (xdhA) |
Xanthine dehydrogenase (in reverse):
urate + NADH + H+→xanthine + NAD+ + H2O (EC 1.17.1.4) |
| HEPCGN_18990 (xdhC) |
| HEPCGN_18995 (xdhB) |
| HEPCGN_19000 (xdhA) |
| xanthine + H2O→5-ureidoimidazole-4-carboxylate + H+ |
| No genes |
| 5-ureidoimidazole-4-carboxylate + 2 H+ + H2O→5-aminoimidazole-4-carboxylate + CO2 + ammonium |
| No genes |
| 5-aminoimidazole-4-carboxylate→CO2 + 4-aminoimidazole |
| No genes |
Aminoimidazolase:
4-aminoimidazole + H+ + H2O→3,5-dihydro-4H-imidazol-4-one + ammonium (EC 3.5.4.8) |
| No genes |
| 3,5-dihydro-4H-imidazol-4-one + H2O→N-formimino-glycine (spontaneous) |
| No genes |
Glycine formimidoyltransferase (in reverse):
N-formimino-glycine + a tetrahydrofolate→5-formimidoyltetrahydrofolate + glycine (EC 2.1.2.4) |
| No genes |
Formimidoyltetrahydrofolate cyclodeaminase:
5-formimidoyltetrahydrofolate + 2 H+→a 5,10-methenyltetrahydrofolate + ammonium (EC 4.3.1.4) |
| No genes |
Methenyltetrahydrofolate cyclohydrolase:
a 5,10-methenyltetrahydrofolate + H2O→an N10-formyltetrahydrofolate + H+ (EC 3.5.4.9) |
| HEPCGN_06445 |
Methylenetetrahydrofolate dehydrogenase (NADP(+)) (in reverse):
a 5,10-methenyltetrahydrofolate + NADPH→a 5,10-methylenetetrahydrofolate + NADP+ (EC 1.5.1.5) |
| HEPCGN_06445 |
Formyltetrahydrofolate deformylase:
an N10-formyltetrahydrofolate + H2O→formate + H+ + a tetrahydrofolate (EC 3.5.1.10) |
| HEPCGN_25030 (purU) |
Glycine hydroxymethyltransferase (in reverse):
glycine + a 5,10-methylenetetrahydrofolate + H2O→L-serine + a tetrahydrofolate (EC 2.1.2.1) |
| HEPCGN_20655 (glyA) |
| formate + NAD+→CO2 + NADH (EC 1.17.1.9) |
| HEPCGN_12585 (fdhD) |
| HEPCGN_12595 (fdoH) |
| HEPCGN_12600 (fdoI) |
| HEPCGN_26410 (fdnI) |
| HEPCGN_26545 (ydeO) |
| HEPCGN_26555 (ydeP) |
L-serine ammonia-lyase:
L-serine→2-aminoprop-2-enoate + H2O (EC 4.3.1.17) |
| HEPCGN_04940 (sdaA) |
| HEPCGN_17260 (tdcG) |
| HEPCGN_19430 (sdaB) |
Tryptophanase:
2-aminoprop-2-enoate→2-iminopropanoate (spontaneous) (EC 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2) |
| HEPCGN_04150 (dcyD) |
| HEPCGN_04940 (sdaA) |
| HEPCGN_13670 (tnaA) |
| HEPCGN_14135 |
| HEPCGN_17260 (tdcG) |
| HEPCGN_19430 (sdaB) |
| HEPCGN_21655 (dsdA) |
| 2-iminopropanoate + H2O→pyruvate + ammonium (spontaneous) (EC 3.5.99.10; 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2) |
| HEPCGN_04150 (dcyD) |
| HEPCGN_04940 (sdaA) |
| HEPCGN_10070 (ridA) |
| HEPCGN_13670 (tnaA) |
| HEPCGN_14135 |
| HEPCGN_17255 (tdcF) |
| HEPCGN_17260 (tdcG) |
| HEPCGN_19430 (sdaB) |
| HEPCGN_21655 (dsdA) |
Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→CO2 + acetyl-CoA + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1) |
| HEPCGN_26025 (nifJ) |
Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8) |
| HEPCGN_14165 |
| HEPCGN_21200 (pta) |
| HEPCGN_21995 (pta) |
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15) |
| HEPCGN_04755 (purT) |
| HEPCGN_17245 (tdcD) |
| HEPCGN_21185 (eutP) |
| HEPCGN_21190 (eutQ) |
| HEPCGN_22000 (ackA) |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information