MetaCyc Pathway: superpathway of phospholipid biosynthesis III (E. coli) in Escherichia coli ECOR38

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Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) (in reverse):
glycerone phosphate + NAD(P)H + H+→sn-glycerol 3-phosphate + NAD(P)+ (EC 1.1.1.94)
HEPCGN_14595 (gpsA)
Glycerol-3-phosphate O-acyltransferase:
sn-glycerol 3-phosphate + an acyl-[acyl-carrier protein]→a 2-lysophosphatidate + a soluble [acyl-carrier protein] (EC 2.3.1.15)
HEPCGN_11595 (plsB)
HEPCGN_17550 (plsY)
HEPCGN_23890 (plsX)
Glycerol-3-phosphate O-acyltransferase:
sn-glycerol 3-phosphate + an acyl-CoA→a 2-lysophosphatidate + coenzyme A (EC 2.3.1.15)
HEPCGN_11595 (plsB)
HEPCGN_17550 (plsY)
HEPCGN_23890 (plsX)
1-acylglycerol-3-phosphate O-acyltransferase:
a 2-lysophosphatidate + an acyl-[acyl-carrier protein]→a phosphatidate + a soluble [acyl-carrier protein] (EC 2.3.1.51)
HEPCGN_12795 (yihG)
HEPCGN_17775 (plsC)
1-acylglycerol-3-phosphate O-acyltransferase:
a 2-lysophosphatidate + an acyl-CoA→a phosphatidate + coenzyme A (EC 2.3.1.51)
HEPCGN_12795 (yihG)
HEPCGN_17775 (plsC)
Phosphatidate cytidylyltransferase:
a phosphatidate + CTP + H+→a CDP-diacylglycerol + diphosphate (EC 2.7.7.41)
HEPCGN_08135 (cdsA)
HEPCGN_08140 (uppS)
HEPCGN_26090 (ynbB)
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase:
a CDP-diacylglycerol + sn-glycerol 3-phosphate→a phosphatidylglycerophosphate + CMP + H+ (EC 2.7.8.5)
HEPCGN_04185 (pgsA)
HEPCGN_26085 (pgsA)
CDP-diacylglycerol--serine O-phosphatidyltransferase:
a CDP-diacylglycerol + L-serine→a phosphatidylserine + CMP + H+ (EC 2.7.8.8)
HEPCGN_20435 (pssA)
HEPCGN_20440 (pssL)
Phosphatidylglycerophosphatase:
a phosphatidylglycerophosphate + H2O→a phosphatidylglycerol + phosphate (EC 3.1.3.27)
HEPCGN_07060 (pgpA)
HEPCGN_20600 (yfhb)
HEPCGN_25635 (pgpB)
Phosphatidylserine decarboxylase:
a phosphatidylserine + H+→a phosphatidylethanolamine + CO2 (EC 4.1.1.65)
HEPCGN_10550 (asd)
2 a phosphatidylglycerol→a cardiolipin + glycerol (EC 2.7.8.41)
HEPCGN_01710 (clsB)
HEPCGN_25125 (clsA)
a phosphatidylethanolamine + a phosphatidylglycerol→a cardiolipin + ethanolamine (EC 2.7.8.41)
HEPCGN_23680 (clsC)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information