MetaCyc Pathway: pentose phosphate pathway in Escherichia coli ECOR38

MetaCyc Pathway: pentose phosphate pathway in Escherichia coli ECOR38

Glucose-6-phosphate dehydrogenase:
D-glucopyranose 6-phosphate + NADP⁺→6-phospho D-glucono-1,5-lactone + NADPH + H⁺ (EC 1.1.1.49)

HEPCGN_04740 (zwf)

6-phosphogluconolactonase:
6-phospho D-glucono-1,5-lactone + H₂O→D-gluconate 6-phosphate + H⁺ (EC 3.1.1.31)

HEPCGN_01600 (pgl)

Phosphogluconate dehydrogenase (decarboxylating):
D-gluconate 6-phosphate + NADP⁺→D-ribulose 5-phosphate + CO₂ + NADPH (EC 1.1.1.44)

HEPCGN_03175 (gndA)

Ribose-5-phosphate isomerase (in reverse):
D-ribulose 5-phosphate→D-ribose 5-phosphate (EC 5.3.1.6)

HEPCGN_11335 (rpiB)

HEPCGN_18755 (rpiA)

Ribulose-phosphate 3-epimerase:
D-ribulose 5-phosphate→D-xylulose 5-phosphate (EC 5.1.3.1)

HEPCGN_15950 (rpe)

Transketolase (in reverse):
D-ribose 5-phosphate + D-xylulose 5-phosphate→D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (EC 2.2.1.1)

HEPCGN_18630 (tkt)

HEPCGN_21165 (tkt)

Transaldolase:
D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate→D-erythrose 4-phosphate + β-D-fructofuranose 6-phosphate (EC 2.2.1.2)

HEPCGN_01905 (fsa)

HEPCGN_12285 (fsa)

HEPCGN_21170 (tal)

Transketolase:
D-erythrose 4-phosphate + D-xylulose 5-phosphate→β-D-fructofuranose 6-phosphate + D-glyceraldehyde 3-phosphate (EC 2.2.1.1)

HEPCGN_18630 (tkt)

HEPCGN_21165 (tkt)

Links:

Pathway details at MetaCyc
Fitness data for 14 genes
Select organism:
All MetaCyc pathways for Escherichia coli ECOR38

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information