MetaCyc Pathway: pyruvate fermentation to acetate and (<i>S</i>)-lactate I in Escherichia coli ECOR38

MetaCyc Pathway: pyruvate fermentation to acetate and (S)-lactate I in Escherichia coli ECOR38

L-lactate dehydrogenase (in reverse):
pyruvate + NADH + H⁺→(S)-lactate + NAD⁺ (EC 1.1.1.27)

HEPCGN_07625 (ykgF)

HEPCGN_07630 (ykgE)

pyruvate + coenzyme A + NAD⁺→acetyl-CoA + CO₂ + NADH (EC 1.2.1.104)

HEPCGN_08470 (lpdA)

HEPCGN_08475 (aceF)

HEPCGN_08480 (aceE)

Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)

HEPCGN_21200 (pta)

HEPCGN_21995 (pta)

Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)

HEPCGN_04755 (purT)

HEPCGN_17245 (tdcD)

HEPCGN_21185 (eutP)

HEPCGN_21190 (eutQ)

HEPCGN_22000 (ackA)

Links:

Pathway details at MetaCyc
Fitness data for 15 genes
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All MetaCyc pathways for Escherichia coli ECOR38

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information