Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4) |
| HEPCGN_09115 (thrA) |
| HEPCGN_11690 (lysC) |
| HEPCGN_12340 (metL) |
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11) |
| HEPCGN_15690 (asd) |
| HEPCGN_21870 (usg) |
| L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7) |
| HEPCGN_21085 (dapA) |
| (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8) |
| HEPCGN_08940 (dapB) |
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase:
(S)-2,3,4,5-tetrahydrodipicolinate + succinyl-CoA + H2O→N-succinyl-2-amino-6-ketopimelate + coenzyme A (EC 2.3.1.117) |
| HEPCGN_08190 (dapD) |
Succinyldiaminopimelate transaminase (in reverse):
N-succinyl-2-amino-6-ketopimelate + L-glutamate→N-succinyl-L,L-2,6-diaminopimelate + 2-oxoglutarate (EC 2.6.1.17) |
| HEPCGN_16055 (argD,dapC) |
| HEPCGN_23030 (serC) |
Succinyl-diaminopimelate desuccinylase:
N-succinyl-L,L-2,6-diaminopimelate + H2O→L,L-diaminopimelate + succinate (EC 3.5.1.18) |
| HEPCGN_21125 (dapE) |
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate (EC 5.1.1.7) |
| HEPCGN_04740 (zwf) |
| HEPCGN_13135 (dapF) |
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2 (EC 4.1.1.20) |
| HEPCGN_19565 (lysA) |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information