MetaCyc Pathway: L-lysine degradation I in Escherichia coli ECOR27

Add experiment(s):


Lysine decarboxylase:
L-lysine + H+→cadaverine + CO2 (EC 4.1.1.18)
NOLOHH_02470 (ldcC)
NOLOHH_04740 (cadA)
Putrescine aminotransferase:
cadaverine + 2-oxoglutarate→5-aminopentanal + L-glutamate (EC 2.6.1.82)
NOLOHH_10415 (ygjG)
Aminobutyraldehyde dehydrogenase:
5-aminopentanal + NAD+ + H2O→5-aminopentanoate + NADH + 2 H+ (EC 1.2.1.19)
NOLOHH_19230 (patD)
5-aminovalerate transaminase:
2-oxoglutarate + 5-aminopentanoate→glutarate semialdehyde + L-glutamate (EC 2.6.1.48)
NOLOHH_12735 (gabT)
NOLOHH_20105 (puuE)
Glutarate-semialdehyde dehydrogenase:
glutarate semialdehyde + NADP+ + H2O→glutarate + NADPH + 2 H+ (EC 1.2.1.20)
NOLOHH_12740 (gabD)
NOLOHH_18760 (sad)
2-oxoglutarate + glutarate + dioxygen→(S)-2-hydroxyglutarate + CO2 + succinate (EC 1.14.11.64)
NOLOHH_12750 (csiD)
(S)-2-hydroxyglutarate + an electron-transfer quinone→2-oxoglutarate + an electron-transfer quinol (EC 1.1.5.13)
NOLOHH_12745 (lhgO)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information