MetaCyc Pathway: lipoprotein posttranslational modification (Gram-negative bacteria) in Escherichia coli ECOR27

a [prolipoprotein]-L-cysteine[in]→a [prolipoprotein]-L-cysteine[membrane]

No genes

a [prolipoprotein]-L-cysteine + a phosphatidylglycerol→a [prolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine + H+ + sn-glycerol 1-phosphate (EC 2.5.1.145)

NOLOHH_11895 (lgt)

Signal peptidase II: a [prolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine + H2O→an (S-diacyl-sn-glyceryl)-L-cysteinyl-[apolipoprotein] + a lipoprotein signal peptide (EC 3.4.23.36)

NOLOHH_03305 (lspA)

an (S-diacyl-sn-glyceryl)-L-cysteinyl-[apolipoprotein] + a phosphoglyceride→an N-acyl-(S-diacyl-sn-glyceryl)-L-cysteinyl-[lipoprotein] + a 1-lysophospholipid + H+ (EC 2.3.1.269)

NOLOHH_23625 (lnt)

a lipoprotein signal peptide + n H2O→n+1 a peptide

NOLOHH_02520 (rseP)

NOLOHH_17325 (sppA)

an N-acyl-(S-diacyl-sn-glyceryl)-L-cysteinyl-[lipoprotein][membrane] + ATP[in] + a LolA lipoprotein chaperone[out] + H2O[in]→a LolA-lipoprotein complex[out] + ADP[in] + H+[in] + phosphate[in]

NOLOHH_00960 (ybbA)

NOLOHH_08510 (ftsE)

NOLOHH_20975 (lolE)

NOLOHH_20980 (lolD)

NOLOHH_20985 (lolC)

a LolA-lipoprotein complex[in]→an N-acyl-(S-diacyl-sn-glyceryl)-L-cysteinyl-[lipoprotein][membrane] + a LolA lipoprotein chaperone[in]

NOLOHH_20620 (lolB)

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information