MetaCyc Pathway: anaerobic energy metabolism (invertebrates, mitochondrial) in Escherichia coli ECOR27

Add experiment(s):


Malate dehydrogenase (oxaloacetate-decarboxylating):
(S)-malate + NAD+→CO2 + pyruvate + NADH (EC 1.1.1.38)
NOLOHH_19035 (maeA)
Fumarate hydratase:
(S)-malate→fumarate + H2O (EC 4.2.1.2)
NOLOHH_04790 (fumB)
NOLOHH_11260 (fumE)
NOLOHH_17815 (fumD)
NOLOHH_18150 (fumB)
NOLOHH_18155 (fumC)
pyruvate + coenzyme A + NAD+→CO2 + acetyl-CoA + NADH (EC 1.2.1.104)
NOLOHH_02835 (lpdA)
NOLOHH_02840 (aceF)
NOLOHH_02845 (aceE)
Succinate dehydrogenase (ubiquinone) (in reverse):
fumarate[in] + a rhodoquinol→succinate[in] + a rhodoquinone (EC 1.3.5.1)
No genes
acetyl-CoA + succinate→acetate + succinyl-CoA (EC 2.8.3.18)
No genes
succinate + propanoyl-CoA→succinyl-CoA + propanoate (EC 2.8.3.27)
NOLOHH_11335 (scpC)
Methylmalonyl-CoA mutase (in reverse):
succinyl-CoA→(R)-methylmalonyl-CoA (EC 5.4.99.2)
NOLOHH_11350 (scpA)
Succinate--CoA ligase (ADP-forming) (in reverse):
succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
NOLOHH_23300 (sucD)
NOLOHH_23305 (sucC)
Methylmalonyl-CoA epimerase:
(R)-methylmalonyl-CoA→(S)-methylmalonyl-CoA (EC 5.1.99.1)
No genes
Propionyl-CoA carboxylase (in reverse):
(S)-methylmalonyl-CoA + ADP + H+ + phosphate→propanoyl-CoA + ATP + hydrogen carbonate (EC 6.4.1.3)
NOLOHH_02475 (accA)
NOLOHH_14315 (accD)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information