MetaCyc Pathway: pyrimidine deoxyribonucleotides de novo biosynthesis II in Escherichia coli ECOR27

Add experiment(s):


CTP + formate + H+→dCTP + CO2 + H2O (EC 1.1.98.6)
NOLOHH_04170 (nrdD)
UTP + formate + H+→dUTP + CO2 + H2O (EC 1.1.98.6)
NOLOHH_04170 (nrdD)
dCTP deaminase:
dCTP + H+ + H2O→dUTP + ammonium (EC 3.5.4.13)
NOLOHH_15615 (dcd)
dUTP diphosphatase:
dUTP + H2O→dUMP + diphosphate + H+ (EC 3.6.1.23; 3.6.1.9)
NOLOHH_07490 (dut)
NOLOHH_14630 (nudI)
Thymidylate synthase:
dUMP + a 5,10-methylenetetrahydrofolate→dTMP + a 7,8-dihydrofolate (EC 2.1.1.45)
NOLOHH_11900 (thyA)
T(2)-induced deoxynucleotide kinase:
dTMP + ATP→dTDP + ADP (EC 2.7.4.12; 2.7.4.13; 2.7.4.9)
NOLOHH_21080 (yceG)
Nucleoside-diphosphate kinase:
dTDP + ATP→dTTP + ADP (EC 2.7.4.6)
NOLOHH_01075 (adk)
NOLOHH_13355 (ndk)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information