MetaCyc Pathway: superpathway of L-phenylalanine biosynthesis in Escherichia coli ECOR27

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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
NOLOHH_12890 (aroF)
NOLOHH_17655 (aroH)
NOLOHH_23170 (aroG)
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
NOLOHH_08905 (aroB)
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
NOLOHH_12150 (eno)
NOLOHH_17715 (aroD)
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
NOLOHH_09355 (aroE)
NOLOHH_17720 (ydiB)
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
NOLOHH_01525 (aroL)
NOLOHH_08900 (aroK)
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
NOLOHH_22045 (aroA)
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
NOLOHH_14250 (aroC)
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
NOLOHH_12895 (tyrA)
NOLOHH_12900 (pheA)
Prephenate dehydratase:
prephenate + H+→3-phenyl-2-oxopropanoate + CO2 + H2O (EC 4.2.1.51)
NOLOHH_12900 (pheA)
Aspartate transaminase (in reverse):
3-phenyl-2-oxopropanoate + L-glutamate→L-phenylalanine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
NOLOHH_03790 (yjiR)
NOLOHH_05170 (tyrB)
NOLOHH_06780 (ilvE)
NOLOHH_15825 (hisC)
NOLOHH_21940 (aspC)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information