MetaCyc Pathway: superpathway of N-acetylneuraminate degradation in Escherichia coli ECOR27

Add experiment(s):


N-acetyl-β-neuraminate→aceneuramate (EC 5.1.3.24)
NOLOHH_09670 (nanQ)
N-acetylneuraminate lyase:
aceneuramate→N-acetyl-D-mannosamine + pyruvate (EC 4.1.3.3)
NOLOHH_09650 (nanA)
N-acylmannosamine kinase:
N-acetyl-D-mannosamine + ATP→N-acetyl-D-mannosamine 6-phosphate + ADP + H+ (EC 2.7.1.60)
NOLOHH_09665 (nanK)
N-acylglucosamine-6-phosphate 2-epimerase:
N-acetyl-D-mannosamine 6-phosphate→N-acetyl-D-glucosamine 6-phosphate (EC 5.1.3.9)
NOLOHH_09660 (nanE)
N-acetylglucosamine-6-phosphate deacetylase:
N-acetyl-D-glucosamine 6-phosphate + H2O→D-glucosamine 6-phosphate + acetate (EC 3.5.1.25)
NOLOHH_10090 (nagA)
NOLOHH_23545 (nagA)
Glucosamine-6-phosphate deaminase:
D-glucosamine 6-phosphate + H2O→β-D-fructofuranose 6-phosphate + ammonium (EC 3.5.99.6)
NOLOHH_23540 (nagB)
6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
NOLOHH_05965 (pfkA)
NOLOHH_17555 (pfkB)
Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
NOLOHH_11305 (fbaA)
NOLOHH_15445 (fbaB)
Fructose-bisphosphatase:
β-D-fructofuranose 1,6-bisphosphate + H2O→β-D-fructofuranose 6-phosphate + phosphate (EC 3.1.3.11)
NOLOHH_01550 (phoA)
NOLOHH_04205 (fbp)
NOLOHH_05915 (glpX)
NOLOHH_11255 (glpX)
NOLOHH_23110 (ybhA)
Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
NOLOHH_05945 (tpiA)
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
NOLOHH_17260 (gapA)
NOLOHH_19375 (gap)
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
NOLOHH_11300 (pgk)
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
NOLOHH_03485
NOLOHH_07615 (gpmM)
NOLOHH_23165 (gpmA)
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.11)
NOLOHH_23165 (gpmA)
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
NOLOHH_12150 (eno)
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
NOLOHH_16835 (pyk)
NOLOHH_17810 (pykF)
Pyruvate, water dikinase:
pyruvate + ATP + H2O→phosphoenolpyruvate + AMP + 2 H+ + phosphate (EC 2.7.9.2)
NOLOHH_17665 (ppsA)
Formate C-acetyltransferase (in reverse):
pyruvate + coenzyme A→acetyl-CoA + formate (EC 2.3.1.54)
NOLOHH_05760 (pflC)
NOLOHH_05765 (pflD)
NOLOHH_10195 (tdcE)
NOLOHH_13015 (grcA)
NOLOHH_22070 (pflB)
NOLOHH_22075 (pflA)
NOLOHH_22485 (ybiY)
NOLOHH_22490 (ybiW)
Acetaldehyde dehydrogenase (acetylating) (in reverse):
acetyl-CoA + NADH + H+→acetaldehyde + coenzyme A + NAD+ (EC 1.2.1.10)
NOLOHH_01680 (mhpF)
NOLOHH_13725 (eutE)
NOLOHH_20445 (adhE)
Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)
NOLOHH_13710 (pta)
NOLOHH_14410 (pta)
NOLOHH_15965
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
NOLOHH_10190 (tdcD)
NOLOHH_13695 (eutP)
NOLOHH_13700 (eutQ)
NOLOHH_14415 (ackA)
NOLOHH_16860 (purT)
Alcohol dehydrogenase (in reverse):
acetaldehyde + NADH + H+→ethanol + NAD+ (EC 1.1.1.1)
NOLOHH_01650 (frmA)
NOLOHH_01805 (yahK)
NOLOHH_04010 (ahr)
NOLOHH_07750 (yiaY)
NOLOHH_09500 (acuI)
NOLOHH_19040 (adhP)
NOLOHH_20445 (adhE)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information