MetaCyc Pathway: pyruvate fermentation to acetate and (<i>S</i>)-lactate I in Escherichia coli ECOR27

MetaCyc Pathway: pyruvate fermentation to acetate and (S)-lactate I in Escherichia coli ECOR27

L-lactate dehydrogenase (in reverse):
pyruvate + NADH + H⁺→(S)-lactate + NAD⁺ (EC 1.1.1.27)

NOLOHH_01915 (ykgF)

NOLOHH_01920 (ykgE)

pyruvate + coenzyme A + NAD⁺→acetyl-CoA + CO₂ + NADH (EC 1.2.1.104)

NOLOHH_02835 (lpdA)

NOLOHH_02840 (aceF)

NOLOHH_02845 (aceE)

Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)

NOLOHH_13710 (pta)

NOLOHH_14410 (pta)

Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)

NOLOHH_10190 (tdcD)

NOLOHH_13695 (eutP)

NOLOHH_13700 (eutQ)

NOLOHH_14415 (ackA)

NOLOHH_16860 (purT)

Links:

Pathway details at MetaCyc
Fitness data for 13 genes
Select organism:
All MetaCyc pathways for Escherichia coli ECOR27

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information