MetaCyc Pathway: superpathway of methylglyoxal degradation in Escherichia coli ECOR27

Add experiment(s):


Methylglyoxal reductase (NADPH-dependent) (in reverse):
methylglyoxal + NADPH + H+→(S)-lactaldehyde + NADP+ (EC 1.1.1.283)
NOLOHH_01940 (aRA1)
Lactoylglutathione lyase (in reverse):
methylglyoxal + glutathione→(R)-S-lactoylglutathione (EC 4.4.1.5)
NOLOHH_17950
Aldehyde reductase (in reverse):
methylglyoxal + NADPH + H+→hydroxyacetone + NADP+ (EC 1.1.1.21)
NOLOHH_02350 (dkgB)
NOLOHH_10710 (dkgA)
NOLOHH_10720 (yqhD)
NOLOHH_10765 (gpr)
NOLOHH_17250 (yeaE)
Hydroxyacylglutathione hydrolase:
(R)-S-lactoylglutathione + H2O→(R)-lactate + glutathione + H+ (EC 3.1.2.6)
NOLOHH_02325 (gloB)
NOLOHH_15085 (yeiG)
NOLOHH_21950 (gloC)
Lactaldehyde dehydrogenase:
(S)-lactaldehyde + NAD+ + H2O→(S)-lactate + NADH + 2 H+ (EC 1.2.1.22)
NOLOHH_19380 (aldA)
hydroxyacetone + NADH + H+→(S)-propane-1,2-diol + NAD+
NOLOHH_05790 (gldA)
(S)-lactate[in] + an electron-transfer quinone→pyruvate[in] + an electron-transfer quinol (EC 1.1.5.M6)
NOLOHH_07650 (lldD)
(R)-lactate[in] + an electron-transfer quinone→pyruvate[in] + an electron-transfer quinol (EC 1.1.5.12)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information