MetaCyc Pathway: superpathway of histidine, purine, and pyrimidine biosynthesis in Dickeya dadantii 3937

Carbamoyl-phosphate synthase (glutamine-hydrolyzing): L-glutamine + hydrogen carbonate + 2 ATP + H2O→carbamoyl phosphate + 2 ADP + L-glutamate + 2 H+ + phosphate (EC 6.3.5.5)

DDA3937_RS18305

DDA3937_RS18310

Ribose-phosphate diphosphokinase: D-ribose 5-phosphate + ATP→5-phospho-α-D-ribose 1-diphosphate + AMP + H+ (EC 2.7.6.1)

DDA3937_RS11010

Aspartate carbamoyltransferase: carbamoyl phosphate + L-aspartate→N-carbamoyl-L-aspartate + H+ + phosphate (EC 2.1.3.2)

DDA3937_RS01920

DDA3937_RS01925

ATP phosphoribosyltransferase (in reverse): 5-phospho-α-D-ribose 1-diphosphate + ATP→1-(5-phospho-β-D-ribosyl)-ATP + diphosphate (EC 2.4.2.17)

DDA3937_RS09740

Amidophosphoribosyltransferase (in reverse): 5-phospho-α-D-ribose 1-diphosphate + L-glutamine + H2O→5-phospho-β-D-ribosylamine + L-glutamate + diphosphate (EC 2.4.2.14)

DDA3937_RS14435

Dihydroorotase (in reverse): N-carbamoyl-L-aspartate + H+→(S)-dihydroorotate + H2O (EC 3.5.2.3)

DDA3937_RS13170

Phosphoribosylamine--glycine ligase: 5-phospho-β-D-ribosylamine + ATP + glycine→N1-(5-phospho-β-D-ribosyl)glycinamide + ADP + H+ + phosphate (EC 6.3.4.13)

DDA3937_RS01215

Phosphoribosyl-ATP diphosphatase: 1-(5-phospho-β-D-ribosyl)-ATP + H2O→1-(5-phospho-β-D-ribosyl)-AMP + diphosphate + H+ (EC 3.6.1.31)

DDA3937_RS09705

Dihydroorotate dehydrogenase: (S)-dihydroorotate[in] + an electron-transfer quinone→orotate[in] + an electron-transfer quinol (EC 1.3.5.2)

DDA3937_RS12855

N1-(5-phospho-β-D-ribosyl)glycinamide + ATP + formate→N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + ADP + H+ + phosphate (EC 6.3.1.21)

DDA3937_RS10145

Phosphoribosyl-AMP cyclohydrolase: 1-(5-phospho-β-D-ribosyl)-AMP + H2O→1-(5-phospho-β-D-ribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide (EC 3.5.4.19)

DDA3937_RS09705

Phosphoribosylformylglycinamidine synthase: N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + L-glutamine + ATP + H2O→2-(formamido)-N1-(5-phospho-β-D-ribosyl)acetamidine + ADP + L-glutamate + H+ + phosphate (EC 6.3.5.3)

DDA3937_RS15655

Orotate phosphoribosyltransferase (in reverse): orotate + 5-phospho-α-D-ribose 1-diphosphate→orotidine 5'-phosphate + diphosphate (EC 2.4.2.10)

DDA3937_RS17820

DDA3937_RS20535

isomerase: 1-(5-phospho-β-D-ribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide→phosphoribulosylformimino-AICAR-phosphate (EC 5.3.1.16)

DDA3937_RS09715

Phosphoribosylformylglycinamidine cyclo-ligase: 2-(formamido)-N1-(5-phospho-β-D-ribosyl)acetamidine + ATP→5-amino-1-(5-phospho-β-D-ribosyl)imidazole + ADP + H+ + phosphate (EC 6.3.3.1)

DDA3937_RS06025

phosphoribulosylformimino-AICAR-phosphate + L-glutamine→5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)-glycerol 3-phosphate + L-glutamate + H+ (EC 4.3.2.10)

DDA3937_RS09710

DDA3937_RS09720

Orotidine-5'-phosphate decarboxylase: orotidine 5'-phosphate + H+→UMP + CO2 (EC 4.1.1.23)

DDA3937_RS12525

Imidazoleglycerol-phosphate dehydratase: D-erythro-1-(imidazol-4-yl)-glycerol 3-phosphate→3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O (EC 4.2.1.19)

DDA3937_RS09725

Cytidylate kinase: UMP + ATP→UDP + ADP (EC 2.7.4.14; 2.7.4.22)

DDA3937_RS05125

DDA3937_RS09680

5-(carboxyamino)imidazole ribonucleotide synthase: 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + hydrogen carbonate + ATP→N5-carboxyaminoimidazole ribonucleotide + ADP + 2 H+ + phosphate (EC 6.3.4.18)

DDA3937_RS15110

Histidinol-phosphate transaminase (in reverse): 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate→L-histidinol phosphate + 2-oxoglutarate (EC 2.6.1.9)

DDA3937_RS09730

5-(carboxyamino)imidazole ribonucleotide mutase: N5-carboxyaminoimidazole ribonucleotide→5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate (EC 5.4.99.18)

DDA3937_RS15105

Nucleoside-diphosphate kinase: UDP + ATP→UTP + ADP (EC 2.7.4.6)

DDA3937_RS05800

DDA3937_RS15485

CTP synthase: UTP + L-glutamine + ATP + H2O→CTP + ADP + L-glutamate + 2 H+ + phosphate (EC 6.3.4.2)

DDA3937_RS01275

DDA3937_RS17005

Histidinol-phosphatase: L-histidinol phosphate + H2O→histidinol + phosphate (EC 3.1.3.15)

DDA3937_RS00860

DDA3937_RS09725

DDA3937_RS11790

Phosphoribosylaminoimidazolesuccinocarboxamide synthase: L-aspartate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP→5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole + ADP + H+ + phosphate (EC 6.3.2.6)

DDA3937_RS06075

Adenylosuccinate lyase: 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole→5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + fumarate (EC 4.3.2.2)

DDA3937_RS11495

DDA3937_RS19965

Histidinol dehydrogenase: histidinol + NAD+→histidinal + NADH + H+ (EC 1.1.1.23)

DDA3937_RS09735

Phosphoribosylaminoimidazolecarboxamide formyltransferase: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + an N10-formyltetrahydrofolate→5-formamido-1-(5-phospho-D-ribosyl)-imidazole-4-carboxamide + a tetrahydrofolate (EC 2.1.2.3)

DDA3937_RS01220

Histidinol dehydrogenase: histidinal + NAD+ + H2O→L-histidine + NADH + 2 H+ (EC 1.1.1.23)

DDA3937_RS09735

IMP cyclohydrolase (in reverse): 5-formamido-1-(5-phospho-D-ribosyl)-imidazole-4-carboxamide→IMP + H2O (EC 3.5.4.10)

DDA3937_RS01220

Adenylosuccinate synthase: IMP + L-aspartate + GTP→adenylosuccinate + GDP + 2 H+ + phosphate (EC 6.3.4.4)

DDA3937_RS18585

IMP dehydrogenase: IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)

DDA3937_RS15420

Adenylosuccinate lyase: adenylosuccinate→AMP + fumarate (EC 4.3.2.2)

DDA3937_RS11495

DDA3937_RS19965

GMP synthase (glutamine-hydrolyzing): XMP + L-glutamine + ATP + H2O→GMP + AMP + L-glutamate + diphosphate + 2 H+ (EC 6.3.5.2)

DDA3937_RS08320

DDA3937_RS14185

DDA3937_RS15415

Adenylate kinase: AMP + ATP→2 ADP (EC 2.7.4.3)

DDA3937_RS05800

Guanylate kinase: GMP + ATP→GDP + ADP (EC 2.7.4.8)

DDA3937_RS00190

DDA3937_RS07635

Ribonucleoside-diphosphate reductase (in reverse): ADP + a reduced thioredoxin→dADP + an oxidized thioredoxin + H2O (EC 1.17.4.1)

DDA3937_RS05870

DDA3937_RS05875

DDA3937_RS16025

DDA3937_RS16030

DDA3937_RS16035

Nucleoside-diphosphate kinase: GDP + ATP→GTP + ADP (EC 2.7.4.6)

DDA3937_RS05800

DDA3937_RS15485

Ribonucleoside-diphosphate reductase (in reverse): GDP + a reduced thioredoxin→dGDP + an oxidized thioredoxin + H2O (EC 1.17.4.1)

DDA3937_RS05870

DDA3937_RS05875

DDA3937_RS16025

DDA3937_RS16030

DDA3937_RS16035

Ribonucleoside-diphosphate reductase (in reverse): ADP + a reduced NrdH glutaredoxin-like protein→dADP + an oxidized NrdH glutaredoxin-like protein + H2O (EC 1.17.4.1)

DDA3937_RS05870

DDA3937_RS05875

DDA3937_RS16030

DDA3937_RS16035

Ribonucleoside-diphosphate reductase (in reverse): GDP + a reduced NrdH glutaredoxin-like protein→dGDP + an oxidized NrdH glutaredoxin-like protein + H2O (EC 1.17.4.1)

DDA3937_RS05870

DDA3937_RS05875

DDA3937_RS16030

DDA3937_RS16035

Nucleoside-diphosphate kinase: dADP + ATP→ADP + dATP (EC 2.7.4.6)

DDA3937_RS15485

Nucleoside-diphosphate kinase: dGDP + ATP→dGTP + ADP (EC 2.7.4.6)

DDA3937_RS05800

DDA3937_RS15485

ATP + formate + H+→dATP + CO2 + H2O (EC 1.1.98.6)

DDA3937_RS01875

GTP + formate + H+→dGTP + CO2 + H2O (EC 1.1.98.6)

DDA3937_RS01875

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information