MetaCyc Pathway: siroheme biosynthesis in Echinicola vietnamensis KMM 6221, DSM 17526

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Uroporphyrinogen-III C-methyltransferase:
uroporphyrinogen-III + S-adenosyl-L-methionine→precorrin-1 + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.107)
Echvi_0980
Echvi_1902
Uroporphyrinogen-III C-methyltransferase:
precorrin-1 + S-adenosyl-L-methionine→precorrin-2 + S-adenosyl-L-homocysteine (EC 2.1.1.107)
Echvi_0980
Echvi_1902
Precorrin-2 dehydrogenase:
precorrin-2 + NAD+→sirohydrochlorin + NADH + 2 H+ (EC 1.3.1.76)
Echvi_0979
Echvi_0980
Echvi_1902
Sirohydrochlorin ferrochelatase:
sirohydrochlorin + Fe2+→siroheme + 2 H+ (EC 4.99.1.4)
Echvi_0979

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information