MetaCyc Pathway: biotin-carboxyl carrier protein assembly in Brevundimonas sp. GW460-12-10-14-LB2

Biotin--[acetyl-CoA-carboxylase] ligase:
a [biotin carboxyl-carrier protein]-L-lysine + ATP + biotin→a [biotin carboxyl-carrier protein]-N⁶-biotinyl-L-lysine + AMP + diphosphate + H⁺ (EC 6.3.4.15)

A4249_RS06335

2 a [biotin carboxyl-carrier protein]-N⁶-biotinyl-L-lysine→a [biotin carboxyl-carrier-protein dimer]-N⁶-biotinyl-L-lysine (spontaneous)

No genes

Biotin carboxylase:
a [biotin carboxyl-carrier-protein dimer]-N⁶-biotinyl-L-lysine + ATP + hydrogen carbonate→a [carboxyl-carrier protein dimer]-N⁶-carboxybiotinyl-L-lysine + ADP + H⁺ + phosphate (EC 6.3.4.14)

a [carboxyl-carrier protein dimer]-N⁶-carboxybiotinyl-L-lysine + acetyl-CoA→a [biotin carboxyl-carrier-protein dimer]-N⁶-biotinyl-L-lysine + malonyl-CoA (EC 2.1.3.15)

A4249_RS04150

A4249_RS11315

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information