MetaCyc Pathway: L-histidine biosynthesis in Brevundimonas sp. GW460-12-10-14-LB2

Add experiment(s):


ATP phosphoribosyltransferase (in reverse):
5-phospho-α-D-ribose 1-diphosphate + ATP→1-(5-phospho-β-D-ribosyl)-ATP + diphosphate (EC 2.4.2.17)
A4249_RS10690
Phosphoribosyl-ATP diphosphatase:
1-(5-phospho-β-D-ribosyl)-ATP + H2O→1-(5-phospho-β-D-ribosyl)-AMP + diphosphate + H+ (EC 3.6.1.31)
A4249_RS10720
Phosphoribosyl-AMP cyclohydrolase:
1-(5-phospho-β-D-ribosyl)-AMP + H2O→1-(5-phospho-β-D-ribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide (EC 3.5.4.19)
A4249_RS10720
isomerase:
1-(5-phospho-β-D-ribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide→phosphoribulosylformimino-AICAR-phosphate (EC 5.3.1.16)
A4249_RS10710
phosphoribulosylformimino-AICAR-phosphate + L-glutamine→5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)-glycerol 3-phosphate + L-glutamate + H+ (EC 4.3.2.10)
A4249_RS10705
A4249_RS10715
Imidazoleglycerol-phosphate dehydratase:
D-erythro-1-(imidazol-4-yl)-glycerol 3-phosphate→3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O (EC 4.2.1.19)
A4249_RS10700
Histidinol-phosphate transaminase (in reverse):
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate→L-histidinol phosphate + 2-oxoglutarate (EC 2.6.1.9)
A4249_RS11450
Histidinol-phosphatase:
L-histidinol phosphate + H2O→histidinol + phosphate (EC 3.1.3.15)
A4249_RS10700
A4249_RS12470
A4249_RS13805
Histidinol dehydrogenase:
histidinol + NAD+→histidinal + NADH + H+ (EC 1.1.1.23)
A4249_RS10695
Histidinol dehydrogenase:
histidinal + NAD+ + H2O→L-histidine + NADH + 2 H+ (EC 1.1.1.23)
A4249_RS10695

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information