MetaCyc Pathway: biotin biosynthesis I in Bosea sp. OAE506

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a malonyl-[acp] + S-adenosyl-L-methionine→a malonyl-[acp] methyl ester + S-adenosyl-L-homocysteine (EC 2.1.1.197)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a malonyl-[acp] + a malonyl-[acp] methyl ester + H+→a 3-oxoglutaryl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABIE41_RS00380
ABIE41_RS04940
ABIE41_RS04945
ABIE41_RS17750
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
ABIE41_RS01135
ABIE41_RS01630
ABIE41_RS02330
ABIE41_RS02405
ABIE41_RS02830
ABIE41_RS04415
ABIE41_RS04935
ABIE41_RS05140
ABIE41_RS07515
ABIE41_RS09100
ABIE41_RS09170
ABIE41_RS10665
ABIE41_RS11110
ABIE41_RS13100
ABIE41_RS13185
ABIE41_RS15455
ABIE41_RS17310
ABIE41_RS17685
ABIE41_RS17760
ABIE41_RS20560
ABIE41_RS20760
ABIE41_RS20775
ABIE41_RS22295
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyglutaryl-[acp] methyl ester→a (2E)-enoylglutaryl-[acp] methyl ester + H2O (EC 4.2.1.59)
ABIE41_RS00385
ABIE41_RS04950
ABIE41_RS17560
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylglutaryl-[acp] methyl ester + NADH + H+→a glutaryl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
ABIE41_RS00370
ABIE41_RS10220
ABIE41_RS22505
Beta-ketoacyl-acyl-carrier-protein synthase II:
a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+→a 3-oxopimeloyl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABIE41_RS00380
ABIE41_RS04940
ABIE41_RS04945
ABIE41_RS17750
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
ABIE41_RS01135
ABIE41_RS01630
ABIE41_RS02330
ABIE41_RS02405
ABIE41_RS02830
ABIE41_RS04415
ABIE41_RS04935
ABIE41_RS05140
ABIE41_RS07515
ABIE41_RS09100
ABIE41_RS09170
ABIE41_RS10665
ABIE41_RS11110
ABIE41_RS13100
ABIE41_RS13185
ABIE41_RS15455
ABIE41_RS17310
ABIE41_RS17685
ABIE41_RS17760
ABIE41_RS20560
ABIE41_RS20760
ABIE41_RS20775
ABIE41_RS22295
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxypimeloyl-[acp] methyl ester→a (2E)-enoylpimeloyl-[acp] methyl ester + H2O (EC 4.2.1.59)
ABIE41_RS00385
ABIE41_RS04950
ABIE41_RS17560
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylpimeloyl-[acp] methyl ester + NADH + H+→a pimeloyl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
ABIE41_RS00370
ABIE41_RS10220
ABIE41_RS22505
a pimeloyl-[acp] methyl ester + H2O→a pimeloyl-[acp] + methanol + H+ (EC 3.1.1.85)
No genes
8-amino-7-oxononanoate synthase:
a pimeloyl-[acp] + L-alanine + H+→(8S)-8-amino-7-oxononanoate + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.47)
No genes
Adenosylmethionine--8-amino-7-oxononanoate transaminase:
(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine→(7R,8S)-diaminononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate (EC 2.6.1.62)
ABIE41_RS12110
Dethiobiotin synthase:
(7R,8S)-diaminononanoate + ATP + CO2→dethiobiotin + ADP + 3 H+ + phosphate (EC 6.3.3.3)
No genes
Biotin synthase:
dethiobiotin + H+ + 2 a reduced [2Fe-2S] ferredoxin + S-adenosyl-L-methionine + a sulfurated [sulfur carrier]→4,5-secobiotin + 5'-deoxyadenosine + L-methionine + 2 an oxidized [2Fe-2S] ferredoxin + an unsulfurated [sulfur carrier] (EC 2.8.1.6)
No genes
Biotin synthase:
4,5-secobiotin + S-adenosyl-L-methionine→biotin + 5'-deoxyadenosine + L-methionine + H+ (EC 2.8.1.6)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information