MetaCyc Pathway: guadinomine B biosynthesis in Phocaeicola dorei CL03T12C01

Add experiment(s):


Glycine amidinotransferase:
L-arginine + glycine→guanidinoacetate + L-ornithine
(EC 2.1.4.1)
No genes
L-serine + ATP + a holo-[L-seryl-carrier protein]→an L-seryl-[L-seryl-carrier protein] + AMP + diphosphate (EC 6.2.1.72)
No genes
Carbamoyl-phosphate synthase (ammonia):
hydrogen carbonate + ATP→carboxyphosphate + ADP
(EC 6.3.4.16; 6.3.5.5)
ABI39_RS02225
ABI39_RS20665
ABI39_RS20670
an L-seryl-[L-seryl-carrier protein][cytosol] + NAD+[cytosol]→a 2-aminomalonyl semialdehyde-[L-seryl-carrier protein][cytosol] + NADH[cytosol] + H+[cytosol]
No genes
Carbamoyl-phosphate synthase (ammonia):
carboxyphosphate + ammonium→carbamate + 2 H+ + phosphate
(EC 6.3.4.16)
No genes
guanidinoacetate + ATP + a holo acp domain within a [polyketide synthase]→guanidinoacetyl-[polyketide synthase] + AMP + diphosphate
No genes
Carbamate kinase:
carbamate + ATP→carbamoyl phosphate + ADP
(EC 2.7.2.2; 6.3.4.16; 6.3.5.5)
ABI39_RS02225
ABI39_RS20665
ABI39_RS20670
a 2-aminomalonyl semialdehyde-[L-seryl-carrier protein] + FAD + H2O→an aminomalonyl-[L-seryl-carrier protein] + FADH2
No genes
an aminomalonyl-[L-seryl-carrier protein] + guanidinoacetyl-[polyketide synthase] + L-glutamate + 2 malonyl-CoA + 8 NADPH + 10 H+→(2S,3S,7R)-2-amino-3-amino-7-hydroxy-8-(2-iminoimidazolidin-4-yl)octanoyl-[GdnH polyketide synthase] + 2-oxoglutarate + CO2 + 2 coenzyme A + 8 NADP+ + 5 H2O + a holo-[L-seryl-carrier protein]
No genes
(2S,3S,7R)-2-amino-3-amino-7-hydroxy-8-(2-iminoimidazolidin-4-yl)octanoyl-[GdnH polyketide synthase] + H2O→(2S,3S,7R)-2-amino-3-amino-7-hydroxy-8-(2-iminoimidazolidin-4-yl)octanoate + a [GdnH polyketide synthase/acyl-carrier protein] + H+
No genes
carbamoyl phosphate + (2S,3S,7R)-2-amino-3-amino-7-hydroxy-8-(2-iminoimidazolidin-4-yl)octanoate→(2S,3S,7R)-2,3-diamino-8-(1-carbamoyl-2-iminoimidazolidin-4-yl)-7-hydroxyoctanoate + phosphate
No genes
(2S,3S,7R)-2,3-diamino-8-(1-carbamoyl-2-iminoimidazolidin-4-yl)-7-hydroxyoctanoate + L-alanyl-L-valine→6-dehydroguadinomine B + H+ + H2O
No genes
6-dehydroguadinomine B + 2-oxoglutarate + dioxygen→guadinomine B + CO2 + succinate (EC 1.14.11.M1)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information