Cholestenone 5-alpha-reductase (in reverse):
progesterone + NADPH + H+→5α-dihydroprogesterone + NADP+ (EC 1.3.1.22) |
| ABI39_RS09975 |
3-beta-hydroxy-5-alpha-steroid dehydrogenase (in reverse):
5α-dihydroprogesterone + NADPH + H+→3β-hydroxy-5α-pregnane-20-one + NADP+ (EC 1.1.1.278) |
| No genes |
Delta(4)-3-oxosteroid 5-beta-reductase (in reverse):
progesterone + NADPH + H+→5β-pregnan-3,20 dione + NADP+ (EC 1.3.1.3) |
| No genes |
3-beta-hydroxy-5-beta-steroid dehydrogenase (in reverse):
5β-pregnan-3,20 dione + NADPH + H+→3β-hydroxy-5β-pregnane-20-one + NADP+ (EC 1.1.1.277) |
| No genes |
| 3β-hydroxy-5β-pregnane-20-one + dioxygen + a reduced [NADPH-hemoprotein reductase]→5β-pregnane-3β,14β-diol-20-one + an oxidized [NADPH-hemoprotein reductase] + H2O |
| No genes |
| 5β-pregnane-3β,14β-diol-20-one + dioxygen + a reduced [NADPH-hemoprotein reductase]→3β,14β,21-trihydroxy-5β-pregnane-20-one + an oxidized [NADPH-hemoprotein reductase] + H2O |
| No genes |
| 3β,14β,21-trihydroxy-5β-pregnane-20-one + malonyl-CoA→3β,14β-dihydroxy-5β-pregnane-20-one-21-O-malonylhemiester + coenzyme A |
| No genes |
| 3β,14β-dihydroxy-5β-pregnane-20-one-21-O-malonylhemiester + H+→(20,21)-dihydro-20-hydroxydigitoxigenin + CO2 (spontaneous) |
| No genes |
| (20,21)-dihydro-20-hydroxydigitoxigenin→digitoxigenin + H2O (spontaneous) |
| No genes |
| digitoxigenin + dioxygen + a reduced [NADPH-hemoprotein reductase]→gitoxigenin + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.M47) |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information