MetaCyc Pathway: superpathway of penicillin, cephalosporin and cephamycin biosynthesis in Phocaeicola dorei CL03T12C01

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N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase:
L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H2O→N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 3 H+ (EC 6.3.2.26)
No genes
Isopenicillin-N synthase:
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + dioxygen→isopenicillin N + 2 H2O (EC 1.21.3.1)
No genes
Isopenicillin-N epimerase:
isopenicillin N→penicillin N (EC 5.1.1.17)
No genes
Isopenicillin-N N-acyltransferase:
isopenicillin N + octanoyl-CoA + H2O→penicillin K + L-2-aminoadipate + coenzyme A + H+ (EC 2.3.1.164)
ABI39_RS06415
Deacetoxycephalosporin-C synthase:
penicillin N + 2-oxoglutarate + dioxygen→deacetoxycephalosporin C + CO2 + succinate + H2O (EC 1.14.20.1)
No genes
Deacetoxycephalosporin-C hydroxylase:
deacetoxycephalosporin C + 2-oxoglutarate + dioxygen→deacetylcephalosporin C + CO2 + succinate (EC 1.14.11.26)
No genes
Deacetylcephalosporin-C acetyltransferase:
deacetylcephalosporin C + acetyl-CoA→cephalosporin C + coenzyme A (EC 2.3.1.175)
No genes
3-hydroxymethylcephem carbamoyltransferase:
deacetylcephalosporin C + carbamoyl phosphate→O-carbamoyl-deacetylcephalosporin C + phosphate (EC 2.1.3.7)
No genes
O-carbamoyl-deacetylcephalosporin C + an oxidized electron carrier + H2O→7-α-hydroxy-O-carbamoyl-deacetylcephalosporin C + a reduced two electron carrier
No genes
7-α-hydroxy-O-carbamoyl-deacetylcephalosporin C + S-adenosyl-L-methionine→cephamycin C + S-adenosyl-L-homocysteine + H+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information