MetaCyc Pathway: L-lysine degradation I in Escherichia coli BL21

MetaCyc Pathway: L-lysine degradation I in Escherichia coli BL21

Lysine decarboxylase:
L-lysine + H⁺→cadaverine + CO₂ (EC 4.1.1.18)

Putrescine aminotransferase:
cadaverine + 2-oxoglutarate→5-aminopentanal + L-glutamate (EC 2.6.1.82)

Aminobutyraldehyde dehydrogenase:
5-aminopentanal + NAD⁺ + H₂O→5-aminopentanoate + NADH + 2 H⁺ (EC 1.2.1.19)

5-aminovalerate transaminase:
2-oxoglutarate + 5-aminopentanoate→glutarate semialdehyde + L-glutamate (EC 2.6.1.48)

Glutarate-semialdehyde dehydrogenase:
glutarate semialdehyde + NADP⁺ + H₂O→glutarate + NADPH + 2 H⁺ (EC 1.2.1.20)

2-oxoglutarate + glutarate + dioxygen→(S)-2-hydroxyglutarate + CO₂ + succinate (EC 1.14.11.64)

(S)-2-hydroxyglutarate + an electron-transfer quinone→2-oxoglutarate + an electron-transfer quinol (EC 1.1.5.13)

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Pathway details at MetaCyc
Fitness data for 10 genes
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All MetaCyc pathways for Escherichia coli BL21

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information