MetaCyc Pathway: cytochrome c biogenesis (system I type) in Escherichia coli BL21

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a reduced thioredoxin[in] + an [oxidized DsbD protein][membrane]→a [reduced DsbD protein][membrane] + an oxidized thioredoxin[in] (EC 1.8.4.16)
ECD_03659
protoheme[in] + an oxidized electron carrier[membrane] + a CcmCDE complex[membrane] + H+[in]→a heme(III)-bound CcmCDE complex[out] + a reduced one electron carrier[membrane]
ECD_02124
ECD_02125
ECD_02126
an apo-[c-type cytochrome] with reduced L-cysteine residues[in]→an apo-[c-type cytochrome] with reduced L-cysteine residues[out]
ECD_03589
a heme(III)-bound CcmCDE complex + ATP + a CcmAB complex→a heme(III)-bound CcmE protein + ADP + a CcmABCD complex + phosphate
ECD_02127
ECD_02128
a [reduced DsbD protein][membrane] + a CcmG protein with an internal disulfide bridge[out]→a CcmG protein with reduced cysteine residues[out] + an [oxidized DsbD protein][membrane] (EC 1.8.4.16)
ECD_04006
an apo-[c-type cytochrome] with reduced L-cysteine residues + an [oxidized DsbA protein]→an apo-[c-type cytochrome] with a dislufide bridge + a [reduced DsbA protein] (EC 1.8.4.15)
ECD_03746
an apo-[c-type cytochrome] with a dislufide bridge + a CcmG protein with reduced cysteine residues→an apo-[c-type cytochrome] with reduced L-cysteine residues + a CcmG protein with an internal disulfide bridge
ECD_02122
an apo-[c-type cytochrome] with reduced L-cysteine residues + a CcmH protein with an internal disulfide bridge→an apo-[c-type cytochrome]--CcmH disulfide
ECD_02121
a heme(III)-bound CcmE protein + an apo-[c-type cytochrome]--CcmH disulfide→a CcmE-[c-type cytochrome--CcmH disulfide] complex
ECD_02123
a CcmE-[c-type cytochrome--CcmH disulfide] complex + a CcmG protein with reduced cysteine residues + an electron-transfer quinol→a CcmH-CcmG disulfide + a c-type cytochrome + a c-type cytochrome biogenesis protein CcmE + an electron-transfer semiquinone + H+
ECD_02122
a CcmH-CcmG disulfide→a CcmH protein with reduced cysteine residues + a CcmG protein with an internal disulfide bridge
ECD_02122

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information