MetaCyc Pathway: anaerobic energy metabolism (invertebrates, mitochondrial) in Escherichia coli BL21

Add experiment(s):


Malate dehydrogenase (oxaloacetate-decarboxylating):
(S)-malate + NAD+→CO2 + pyruvate + NADH (EC 1.1.1.38)
ECD_01437
Fumarate hydratase:
(S)-malate→fumarate + H2O (EC 4.2.1.2)
ECD_01580
ECD_01581
ECD_01644
ECD_02760
ECD_03993
pyruvate + coenzyme A + NAD+→CO2 + acetyl-CoA + NADH (EC 1.2.1.104)
ECD_00113
ECD_00114
ECD_00115
Succinate dehydrogenase (ubiquinone) (in reverse):
fumarate[in] + a rhodoquinol→succinate[in] + a rhodoquinone (EC 1.3.5.1)
No genes
acetyl-CoA + succinate→acetate + succinyl-CoA (EC 2.8.3.18)
No genes
succinate + propanoyl-CoA→succinyl-CoA + propanoate (EC 2.8.3.27)
ECD_02751
Methylmalonyl-CoA mutase (in reverse):
succinyl-CoA→(R)-methylmalonyl-CoA (EC 5.4.99.2)
ECD_02748
Succinate--CoA ligase (ADP-forming) (in reverse):
succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
ECD_00687
ECD_00688
Methylmalonyl-CoA epimerase:
(R)-methylmalonyl-CoA→(S)-methylmalonyl-CoA (EC 5.1.99.1)
No genes
Propionyl-CoA carboxylase (in reverse):
(S)-methylmalonyl-CoA + ADP + H+ + phosphate→propanoyl-CoA + ATP + hydrogen carbonate (EC 6.4.1.3)
ECD_00183
ECD_02241

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information