MetaCyc Pathway: superpathway of thiamine diphosphate biosynthesis II in Azospirillum sp. SherDot2

Add experiment(s):


1-deoxy-D-xylulose-5-phosphate synthase:
D-glyceraldehyde 3-phosphate + H+ + pyruvate→1-deoxy-D-xylulose 5-phosphate + CO2 (EC 2.2.1.7)
MPMX19_05066
5-amino-1-(5-phospho-β-D-ribosyl)imidazole + S-adenosyl-L-methionine→4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + carbon monoxide + 5'-deoxyadenosine + formate + L-methionine + 3 H+ (EC 4.1.99.17)
MPMX19_00336
Glycine oxidase:
glycine + dioxygen→2-iminoacetate + hydrogen peroxide + H+ (EC 1.4.3.19; 1.4.3.3)
MPMX19_00260
a [ThiS sulfur-carrier protein] + ATP + H+→a carboxy-adenylated-[ThiS sulfur-carrier protein] + diphosphate (EC 2.7.7.73)
MPMX19_00239
MPMX19_01310
MPMX19_01865
Cysteine desulfurase:
L-cysteine + an [L-cysteine desulfurase]-L-cysteine→an [L-cysteine desulfurase]-S-sulfanyl-L-cysteine + L-alanine (EC 2.8.1.7)
MPMX19_00470
MPMX19_01655
MPMX19_01848
MPMX19_04754
MPMX19_04833
MPMX19_04963
Phosphomethylpyrimidine kinase:
4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP→4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP (EC 2.7.4.7)
MPMX19_06182
Cysteine desulfurase:
a carboxy-adenylated-[ThiS sulfur-carrier protein] + an [L-cysteine desulfurase]-S-sulfanyl-L-cysteine + a reduced two electron carrier→a thiocarboxylated-[ThiS sulfur-carrier protein] + AMP + an oxidized electron carrier + an [L-cysteine desulfurase]-L-cysteine + 2 H+ (EC 2.8.1.7)
MPMX19_00470
MPMX19_01655
MPMX19_01848
MPMX19_04754
MPMX19_04833
MPMX19_04963
2-iminoacetate + 1-deoxy-D-xylulose 5-phosphate + a thiocarboxylated-[ThiS sulfur-carrier protein]→a [ThiS sulfur-carrier protein] + 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 2 H2O (EC 2.8.1.10)
MPMX19_00262
2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate→2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate (EC 5.3.99.10)
No genes
Thiamine-phosphate diphosphorylase:
4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 2 H+→thiamine phosphate + CO2 + diphosphate (EC 2.5.1.3)
MPMX19_00683
MPMX19_04462
Thiamine-phosphate kinase:
thiamine phosphate + ATP→thiamine diphosphate + ADP (EC 2.7.4.16)
MPMX19_00731

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information