MetaCyc Pathway: L-glutamate degradation V (via hydroxyglutarate) in Azospirillum sp. SherDot2

Add experiment(s):


Glutamate dehydrogenase:
L-glutamate + NAD+ + H2O→2-oxoglutarate + ammonium + NADH + H+ (EC 1.4.1.2)
MPMX19_04621
2-oxoglutarate + NADH + H+→(R)-2-hydroxyglutarate + NAD+ (EC 1.1.1.399)
MPMX19_00753
Glutaconate CoA-transferase:
(R)-2-hydroxyglutarate + acetyl-CoA→(R)-2-hydroxyglutaryl-CoA + acetate (EC 2.8.3.12)
MPMX19_05857
MPMX19_05858
(R)-2-hydroxyglutaryl-CoA→(E)-glutaconyl-CoA + H2O (EC 4.2.1.167)
No genes
(E)-glutaconyl-CoA[in] + Na+[in] + H+[in]→crotonyl-CoA[in] + CO2[in] + Na+[out] (EC 7.2.4.5)
No genes
crotonyl-CoA + H2O→(S)-3-hydroxybutanoyl-CoA (EC 4.2.1.150)
MPMX19_01506
MPMX19_01519
MPMX19_02329
MPMX19_02766
MPMX19_03391
MPMX19_03907
MPMX19_04243
MPMX19_04526
MPMX19_04613
MPMX19_05225
MPMX19_05231
MPMX19_05776
MPMX19_06872
MPMX19_06875
MPMX19_06916
MPMX19_06938
MPMX19_06944
crotonyl-CoA[cytosol] + 2 NADH[cytosol] + 2 an oxidized ferredoxin [iron-sulfur] cluster[cytosol]→butanoyl-CoA[cytosol] + 2 NAD+[cytosol] + 2 a reduced ferredoxin [iron-sulfur] cluster[cytosol] (EC 1.3.1.109)
No genes
Propionate CoA-transferase:
butanoyl-CoA + acetate→acetyl-CoA + butanoate (EC 2.8.3.1; 2.8.3.8)
MPMX19_03462
MPMX19_05365
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
MPMX19_00640
MPMX19_03296
MPMX19_04900
MPMX19_05225
MPMX19_05943
MPMX19_06153
MPMX19_06944
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
MPMX19_01912
MPMX19_03465
MPMX19_03936
MPMX19_04608
MPMX19_04667
MPMX19_04901
MPMX19_05089
MPMX19_05232
MPMX19_05779
MPMX19_05859
MPMX19_06343
MPMX19_06951

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information