MetaCyc Pathway: serotonin degradation in Agrobacterium fabrum C58

Aryl sulfotransferase: serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)

No genes

Monoamine oxidase: serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)

No genes

5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)

No genes

Aldehyde dehydrogenase (NAD(+)): 5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)

Atu2139

Atu2224

Atu3401

Atu3403

Atu3950

Atu3959

Atu4153

Atu4241

Atu4849

Atu5228

Alcohol dehydrogenase (in reverse): 5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)

Atu0626

Atu1557

Atu1595

Atu1670

Atu2022

Atu2138

Atu2151

Atu2528

Atu4236

Atu4289

Atu5074

Atu5138

Atu5202

Atu5240

Aryl sulfotransferase: 5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)

No genes

Glucuronosyltransferase: 5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)

No genes

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information