| Reactions and Genes | PDB |
|---|
| remove |
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4) |
| DDA3937_RS00955 | +0.1 |
| DDA3937_RS18415 | -0.0 |
| DDA3937_RS19020 | -0.1 |
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11) |
| DDA3937_RS14470 | -0.6 |
| DDA3937_RS19765 | N.D. |
| L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7) |
| DDA3937_RS00405 | -0.1 |
| DDA3937_RS06065 | N.D. |
| DDA3937_RS08035 | +0.2 |
| DDA3937_RS17850 | -0.5 |
| DDA3937_RS19685 | +0.1 |
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3) |
| DDA3937_RS00955 | +0.1 |
| DDA3937_RS18415 | -0.0 |
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39) |
| DDA3937_RS18410 | -0.4 |
| (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8) |
| DDA3937_RS18315 | N.D. |
Cystathionine gamma-synthase:
O-phospho-L-homoserine + L-cysteine→L-cystathionine + phosphate (EC 2.5.1.48) |
| DDA3937_RS00950 | -0.1 |
LL-diaminopimelate aminotransferase (in reverse):
(S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H+ + H2O→L,L-diaminopimelate + 2-oxoglutarate (EC 2.6.1.83) |
| No genes |
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1) |
| DDA3937_RS18405 | -0.1 |
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate (EC 5.1.1.7) |
| DDA3937_RS10135 | +0.2 |
| DDA3937_RS19900 | N.D. |
Cysteine-S-conjugate beta-lyase:
L-cystathionine→2-aminoprop-2-enoate + L-homocysteine (EC 4.4.1.13) |
| No genes |
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2 (EC 4.1.1.20) |
| DDA3937_RS07725 | +0.2 |
| DDA3937_RS17425 | -1.2 |
| DDA3937_RS20740 | +0.4 |
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate (EC 2.1.1.14) |
| DDA3937_RS05440 | -0.1 |
| DDA3937_RS11855 | -1.3 |
| DDA3937_RS20380 | -0.0 |
Tryptophanase:
2-aminoprop-2-enoate→2-iminopropanoate (spontaneous) (EC 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2) |
| DDA3937_RS00280 | +0.1 |
| DDA3937_RS07535 | +0.3 |
| DDA3937_RS11265 | -0.6 |
| DDA3937_RS15120 | -0.3 |
| DDA3937_RS18140 | -0.1 |
| 2-iminopropanoate + H2O→pyruvate + ammonium (spontaneous) (EC 3.5.99.10; 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2) |
| DDA3937_RS00280 | +0.1 |
| DDA3937_RS01915 | +0.8 |
| DDA3937_RS07535 | +0.3 |
| DDA3937_RS11265 | -0.6 |
| DDA3937_RS15120 | -0.3 |
| DDA3937_RS18140 | -0.1 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information