MetaCyc Pathway: L-methionine biosynthesis II in Dickeya dadantii 3937

Reactions and Genes	PDB
	remove
Homoserine kinase: L-homoserine + ATP→O-phospho-L-homoserine + ADP + H⁺ (EC 2.7.1.39)
DDA3937_RS18410	-0.4
Cystathionine gamma-synthase: O-phospho-L-homoserine + L-cysteine→L-cystathionine + phosphate (EC 2.5.1.48)
DDA3937_RS00950	-0.1
Cysteine-S-conjugate beta-lyase: L-cystathionine→2-aminoprop-2-enoate + L-homocysteine (EC 4.4.1.13)
No genes
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase: L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate (EC 2.1.1.14)
DDA3937_RS05440	-0.1
DDA3937_RS11855	-1.3
DDA3937_RS20380	-0.0
Tryptophanase: 2-aminoprop-2-enoate→2-iminopropanoate (spontaneous) (EC 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
DDA3937_RS00280	+0.1
DDA3937_RS07535	+0.3
DDA3937_RS11265	-0.6
DDA3937_RS15120	-0.3
DDA3937_RS18140	-0.1
2-iminopropanoate + H₂O→pyruvate + ammonium (spontaneous) (EC 3.5.99.10; 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
DDA3937_RS00280	+0.1
DDA3937_RS01915	+0.8
DDA3937_RS07535	+0.3
DDA3937_RS11265	-0.6
DDA3937_RS15120	-0.3
DDA3937_RS18140	-0.1

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Pathway details at MetaCyc
Fitness data for 11 genes
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All MetaCyc pathways for Dickeya dadantii 3937

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information