MetaCyc Pathway: colanic acid building blocks biosynthesis in Dickeya dianthicola ME23

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Reactions and Genes PDB
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Glucose-6-phosphate isomerase:
α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate (EC 5.3.1.9)
DZA65_RS20220 -0.5
Phosphoglucomutase (in reverse):
D-glucopyranose 6-phosphate→α-D-glucopyranose 1-phosphate (EC 5.4.2.2)
DZA65_RS03205 N.D.
DZA65_RS06745 -1.4
UTP-monosaccharide-1-phosphate uridylyltransferase:
α-D-glucopyranose 1-phosphate + H+ + UTP→UDP-α-D-glucose + diphosphate (EC 2.7.7.64; 2.7.7.9)
DZA65_RS07170 -1.7
DZA65_RS10830 N.D.
Mannose-6-phosphate isomerase (in reverse):
β-D-fructofuranose 6-phosphate→D-mannopyranose 6-phosphate (EC 5.3.1.8)
DZA65_RS11120 +0.8
Phosphomannomutase (in reverse):
D-mannopyranose 6-phosphate→α-D-mannose 1-phosphate (EC 5.4.2.8)
DZA65_RS19725 +1.2
UDP-glucose 4-epimerase:
UDP-α-D-glucose→UDP-α-D-galactose (EC 5.1.3.2)
DZA65_RS03630 +0.6
DZA65_RS06990 -1.0
UDP-glucose 6-dehydrogenase:
UDP-α-D-glucose + 2 NAD+ + H2O→UDP-α-D-glucuronate + 2 NADH + 3 H+ (EC 1.1.1.22)
DZA65_RS07165 N.D.
Mannose-1-phosphate guanylyltransferase:
α-D-mannose 1-phosphate + GTP + H+→GDP-α-D-mannose + diphosphate (EC 2.7.7.13)
DZA65_RS19720 +1.3
GDP-mannose 4,6-dehydratase:
GDP-α-D-mannose→GDP-4-dehydro-α-D-rhamnose + H2O (EC 4.2.1.47)
DZA65_RS19730 +1.0
GDP-L-fucose synthase:
GDP-4-dehydro-α-D-rhamnose→GDP-4-dehydro-6-deoxy-β-L-galactose (EC 1.1.1.271)
DZA65_RS19745 +1.0
GDP-L-fucose synthase (in reverse):
GDP-4-dehydro-6-deoxy-β-L-galactose + NADPH + H+→GDP-β-L-fucose + NADP+ (EC 1.1.1.271)
DZA65_RS19745 +1.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information