MetaCyc Pathway: (S)-lactate fermentation to propanoate, acetate and hydrogen in Dickeya dadantii 3937

Reactions and Genes	Upstate
L-lactate dehydrogenase: (S)-lactate + NAD+→pyruvate + NADH + H+ (EC 1.1.1.27)
DDA3937_RS07200	+0.0
DDA3937_RS07205	-0.7
DDA3937_RS12255	-0.3
DDA3937_RS12260	+0.1
Pyruvate carboxylase: pyruvate + ATP + hydrogen carbonate→oxaloacetate + ADP + H+ + phosphate (EC 6.4.1.1)
No genes
Formate C-acetyltransferase (in reverse): pyruvate + coenzyme A→acetyl-CoA + formate (EC 2.3.1.54)
DDA3937_RS09650	-2.0
DDA3937_RS09655	-2.0
DDA3937_RS15785	-0.0
formate + H+→H2 + CO2
DDA3937_RS07405	-1.0
DDA3937_RS07465	-0.3
Malate dehydrogenase (in reverse): oxaloacetate + NADH + H+→(S)-malate + NAD+ (EC 1.1.1.37; 1.1.1.38)
DDA3937_RS02970	-0.4
DDA3937_RS07530	+0.3
DDA3937_RS08480	-0.8
DDA3937_RS13075	+0.5
Phosphate acetyltransferase: acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)
DDA3937_RS14385	-2.4
Acetate kinase (in reverse): acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
DDA3937_RS10145	-0.2
DDA3937_RS14380	-3.2
Fumarate hydratase: (S)-malate→fumarate + H2O (EC 4.2.1.2)
DDA3937_RS04540	-0.3
DDA3937_RS10655	+0.2
Succinate dehydrogenase (ubiquinone): fumarate[in] + a menaquinol→succinate[in] + a menaquinone (EC 1.3.5.1)
DDA3937_RS18965	-1.3
DDA3937_RS18970	-0.9
DDA3937_RS18975	-0.7
DDA3937_RS18980	-2.5
succinate + propanoyl-CoA→succinyl-CoA + propanoate (EC 2.8.3.27)
No genes
Methylmalonyl-CoA mutase (in reverse): succinyl-CoA→(R)-methylmalonyl-CoA (EC 5.4.99.2)
No genes
Methylmalonyl-CoA epimerase: (R)-methylmalonyl-CoA→(S)-methylmalonyl-CoA (EC 5.1.99.1)
No genes
(S)-methylmalonyl-CoA[in] + Na+[in] + H+[out]→propanoyl-CoA[in] + CO2[in] + Na+[out] (EC 7.2.4.3)
No genes

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information